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Literature DB >> 10548598

Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease.

H Takahashi¹, T Iwata, Y Kitagawa, R H Takahashi, Y Sato, H Wakabayashi, M Takashima, H Kido, K Nagashima, K Kenney, C J Gibbs, T Kurata.

Abstract

We established four hybridoma cell lines producing monoclonal antibodies (MAbs) against 14-3-3 proteins. Immunoblot analysis revealed that epsilon and gamma isoforms were specifically increased in premortem cerebrospinal fluid samples from patients with sporadic Creutzfeldt-Jakob disease. Furthermore, dot immunoblot analysis showed that MAbs were more specific for native antigen than polyclonal antibodies were.

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Year: 1999 PMID： 10548598 PMCID： PMC95810 DOI： 10.1128/CDLI.6.6.983-985.1999

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

11 in total

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2. The 14-3-3 brain protein and transmissible spongiform encephalopathy.

Authors: I Zerr; M Bodemer; T Weber
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3. A novel progressive spongiform encephalopathy in cattle.

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4. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

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Journal: J Mol Biol Date: 1993-06-20 Impact factor: 5.469

2. Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.

Authors: Chang-Hoon Cho; Eunju Kim; Young-Sun Lee; Oleg Yarishkin; Jae Cheal Yoo; Jae-Yong Park; Seong-Geun Hong; Eun Mi Hwang
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3. Early increase of cerebrospinal fluid 14-3-3ζ protein in the alzheimer's disease continuum.

Authors: Yuanyuan Lu
Journal: Front Aging Neurosci Date: 2022-07-29 Impact factor: 5.702

3 in total

Increased levels of epsilon and gamma isoforms of 14-3-3 proteins in cerebrospinal fluid in patients with Creutzfeldt-Jakob disease.

1. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.

2. The 14-3-3 brain protein and transmissible spongiform encephalopathy.

3. A novel progressive spongiform encephalopathy in cattle.

4. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

Review 5. 14-3-3: modulators of signaling proteins?

6. The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies.

Review 7. Diagnosis of Creutzfeldt-Jakob disease and related human spongiform encephalopathies.

8. Abnormal proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

9. Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid.

10. A new variant of Creutzfeldt-Jakob disease in the UK.

Review 1. 14-3-3s are potential biomarkers for HIV-related neurodegeneration.

2. Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.

3. Early increase of cerebrospinal fluid 14-3-3ζ protein in the alzheimer's disease continuum.