Literature DB >> 10548596

Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B.

E M Mascini1, M Jansze, J Verhoef, H van Dijk.   

Abstract

In this pilot study, we investigated the relative avidities for streptococcal pyrogenic exotoxin A (SPE-A) and SPE-B of antibodies in sera from patients with fatal streptococcal toxic shock-like syndrome and from healthy individuals and in intravenous immunoglobulin (IVIG) preparations. We observed a great variation in the relative avidities of patient, control, and IVIG immunoglobulin G (IgG) (values estimated to be between 10(-7) and 10(-11) M), with mean values for patient IgG about 10-fold lower than those of control IgG.

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Year:  1999        PMID： 10548596      PMCID： PMC95808          DOI： 10.1128/CDLI.6.6.977-980.1999

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  15 in total

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9.  Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

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10.  Relation between low capacity of human sera to inhibit streptococcal mitogens and serious manifestation of disease.

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