Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.

Literature DB >> 1054829

The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.

Abstract

The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severly decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1975 PMID： 1054829 PMCID： PMC432335 DOI： 10.1073/pnas.72.2.479

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

1. A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.

Authors: A H ANTON; D F SAYRE
Journal: J Pharmacol Exp Ther Date: 1962-12 Impact factor: 4.030

2. INHIBITION OF THE SYNTHESIS OF PROTEIN IN INTACT ANIMALS BY ACETOXYCYCLOHEXIMIDE AND A METABOLIC DERANGEMENT CONCOMITANT WITH THIS BLOCKADE.

Authors: C W YOUNG; P F ROBINSON; B SACKTOR
Journal: Biochem Pharmacol Date: 1963-08 Impact factor: 5.858

3. A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY.

Authors: T NAGATSU; M LEVITT; S UDENFRIEND
Journal: Anal Biochem Date: 1964-09 Impact factor: 3.365

4. A fluorometric method for the estimation of tyrosine in plasma and tissues.

Authors: T P WAALKES; S UDENFRIEND
Journal: J Lab Clin Med Date: 1957-11

5. Saturation of a shared mechanism which transports L-arginine and L-lysine into the brain of the living rat.

Authors: G Baños; P M Daniel; O E Pratt
Journal: J Physiol Date: 1974-01 Impact factor: 5.182

6. Effect of acetoxycycloheximide on learning and memory of a light-dark discrimination.

Authors: H D Cohen; S H Barondes
Journal: Nature Date: 1968-04-20 Impact factor: 49.962

7. Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

Authors: I J Kopin; G R Breese; K R Krauss; V K Weise
Journal: J Pharmacol Exp Ther Date: 1968-06 Impact factor: 4.030

8. Acquisition, storage, and recall of memory for brightness discrimination by rats following intracerebral infusion of acetoxycycloheximide.

Authors: D Daniels
Journal: J Comp Physiol Psychol Date: 1971-07

The effect of acetoxycycloheximide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory.

1. A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.

2. INHIBITION OF THE SYNTHESIS OF PROTEIN IN INTACT ANIMALS BY ACETOXYCYCLOHEXIMIDE AND A METABOLIC DERANGEMENT CONCOMITANT WITH THIS BLOCKADE.

3. A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY.

4. A fluorometric method for the estimation of tyrosine in plasma and tissues.

5. Saturation of a shared mechanism which transports L-arginine and L-lysine into the brain of the living rat.

6. Effect of acetoxycycloheximide on learning and memory of a light-dark discrimination.

7. Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

8. Acquisition, storage, and recall of memory for brightness discrimination by rats following intracerebral infusion of acetoxycycloheximide.

9. End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.

10. Cycloheximide and acetoxycycloheximide: inhibition of tyrosine hydroxylase activity and amnestic effects.

Review 1. The role of protein synthesis in memory consolidation: progress amid decades of debate.

2. The inhibition of protein synthesis by glutarimide antibiotics and long-term memory.

3. Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.

4. Studies on memory: inhibitors of protein synthesis also inhibit catecholamine synthesis.

Review 5. The neurochemistry of learning and memory.