J McClellan1, C McCurry. 1. University of Washington's Department of Psychiatry, Seattle 98195, USA. drjack@u.washington.edu
Abstract
OBJECTIVES: To examine the clinical features and diagnostic stability of early-onset psychotic disorders. METHODS: These data are from a two-year longitudinal prospective study of youth with psychotic disorders. Standardized diagnostic assessments are administered at baseline and at one and two-year's follow-up. RESULTS: Fifty-one subjects have been recruited to date; 18 with schizophrenia, 14 with bipolar disorder, 7 with schizoaffective disorder, 1 with an organic psychosis, and 11 subjects whose symptoms where either questionable and/or did not meet diagnostic criteria for another disorder (classified as psychosis nos). Thirty-nine subjects were reassessed at year one, twenty-four at year two. Three subjects have been lost to follow-up. The study diagnosis was the same as the first onset diagnosis (prior to entering the study) in 50% of subjects. Over the two-year period of the study, the diagnosis remained unchanged in over 90% of subjects. Subjects with schizophrenia had higher ratings of premorbid impairment, including social withdrawal and dysfunctional peer relationships, than those with bipolar disorder. At the one-year follow-up, subjects with schizophrenia and schizoaffective disorder had significantly higher rates of delusions, bizarre behavior, and negative symptoms than those with bipolar disorder. Subjects with bipolar disorder tended to have cyclical courses, whereas those with schizophrenia and schizoaffective disorder were often chronically impaired. Subjects with psychosis nos had higher rates of dissociative symptoms and histories of child maltreatment. CONCLUSIONS: Early-onset psychotic disorders can be reliably diagnosed using standardized assessments and are stable over a two-year period. Compared to bipolar disorder, schizophrenia is associated with a poorer premorbid history, and persistent positive and negative symptoms.
OBJECTIVES: To examine the clinical features and diagnostic stability of early-onset psychotic disorders. METHODS: These data are from a two-year longitudinal prospective study of youth with psychotic disorders. Standardized diagnostic assessments are administered at baseline and at one and two-year's follow-up. RESULTS: Fifty-one subjects have been recruited to date; 18 with schizophrenia, 14 with bipolar disorder, 7 with schizoaffective disorder, 1 with an organic psychosis, and 11 subjects whose symptoms where either questionable and/or did not meet diagnostic criteria for another disorder (classified as psychosis nos). Thirty-nine subjects were reassessed at year one, twenty-four at year two. Three subjects have been lost to follow-up. The study diagnosis was the same as the first onset diagnosis (prior to entering the study) in 50% of subjects. Over the two-year period of the study, the diagnosis remained unchanged in over 90% of subjects. Subjects with schizophrenia had higher ratings of premorbid impairment, including social withdrawal and dysfunctional peer relationships, than those with bipolar disorder. At the one-year follow-up, subjects with schizophrenia and schizoaffective disorder had significantly higher rates of delusions, bizarre behavior, and negative symptoms than those with bipolar disorder. Subjects with bipolar disorder tended to have cyclical courses, whereas those with schizophrenia and schizoaffective disorder were often chronically impaired. Subjects with psychosis nos had higher rates of dissociative symptoms and histories of child maltreatment. CONCLUSIONS: Early-onset psychotic disorders can be reliably diagnosed using standardized assessments and are stable over a two-year period. Compared to bipolar disorder, schizophrenia is associated with a poorer premorbid history, and persistent positive and negative symptoms.
Authors: Jens Richardt M Jepsen; Birgitte Fagerlund; Anne Katrine Pagsberg; Anne Marie R Christensen; Merete Nordentoft; Erik L Mortensen Journal: Eur Child Adolesc Psychiatry Date: 2010-08-01 Impact factor: 4.785
Authors: Paola Salvatore; Ross J Baldessarini; Mauricio Tohen; Hari-Mandir K Khalsa; Jesus Perez Sanchez-Toledo; Carlos A Zarate; Eduard Vieta; Carlo Maggini Journal: J Clin Psychiatry Date: 2010-07-13 Impact factor: 4.384
Authors: Ditte Lammers Vernal; Anne Dorte Stenstrøm; Nina Staal; Anne Marie Raabjerg Christensen; Christine Ebbesen; Anne Katrine Pagsberg; Christoph U Correll; René Ernst Nielsen; Marlene Briciet Lauritsen Journal: Eur Child Adolesc Psychiatry Date: 2018-01-03 Impact factor: 4.785
Authors: Maria Giuseppina Ledda; Anna Lisa Fratta; Manuela Pintor; Alessandro Zuddas; Carlo Cianchetti Journal: Child Psychiatry Hum Dev Date: 2009-03-12
Authors: Christoph U Correll; Christopher W Smith; Andrea M Auther; Danielle McLaughlin; Manoj Shah; Carmel Foley; Ruth Olsen; Todd Lencz; John M Kane; Barbara A Cornblatt Journal: J Child Adolesc Psychopharmacol Date: 2008-10 Impact factor: 2.576
Authors: Selwyn B Renard; Rafaele J C Huntjens; Paul H Lysaker; Andrew Moskowitz; André Aleman; Gerdina H M Pijnenborg Journal: Schizophr Bull Date: 2016-05-21 Impact factor: 9.306