Cyclopentolate and grand mal seizure.

The author describes a case of grand mal seizures that occurred on two occasions after ocular instillation of cyclopentolate 2% for refraction in a 11-year old epileptic girl. The first and the second crisis developed respectively 45 and 30 minutes after instillation of the drug. Cyclopentolate should be contraindicated in known epileptic children.