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Literature DB >> 1054514

Dimethyl adipimidate: a new antisickling agent.

B H Lubin, V Pena, W C Mentzer, E Bymun, T B Bradley, L Packer.

Abstract

A new approach to the prevention of sickling in vitro by use of the bifunctional crosslinking reagent, dimethyl adipimidate, is described. Prior treatment of sickle erythrocytes with dimethyl adipimidate will inhibit sickling in completely deoxygenated erythrocytes. Treated erythrocytes do not demonstrate the potassium loss and viscosity increase that usually accompany sickling. The oxygen affinity of hemoglobin in these cells is increased independently from changes in the concentration of 2,3-diphosphoglycerate. The hemoglobin obtained from treated erythrocytes contains a high-molecular-weight component as well as additional positively charged components. The relative degree to which chemical modification and/or crosslinking is an essential part of the antisickling properties of the material is not known.

Entities: Chemical

Mesh：

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Year: 1975 PMID： 1054514 PMCID： PMC432236 DOI： 10.1073/pnas.72.1.43

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

14 in total

6. Dimethyl adipimidate/Thin film Sample processing (DTS); A simple, low-cost, and versatile nucleic acid extraction assay for downstream analysis.

Authors: Yong Shin; Swee Yin Lim; Tae Yoon Lee; Mi Kyoung Park
Journal: Sci Rep Date: 2015-09-15 Impact factor: 4.379

6 in total

Dimethyl adipimidate: a new antisickling agent.

1. The effect of methemoglobin formation in sickle cell disease.

2. Oxyhemoglobin dissociation curve correction for temperature and pH variation in human blood.

3. Cross-linking of bovine pancreatic ribonuclease A with dimethyl adipimidate.

4. Sodium cyanate as a potential treatment for sickle-cell disease.

5. Effects of urea and cyanate on sickling in vitro.

6. Hemoglobin Gun Hill: deletion of five amino acid residues and impaired heme-globin binding.

7. Effects of cyanate and 2,3-diphosphoglycerate on sickling. Relationship to oxygenation.

8. The effects of sickling on ion transport. I. Effect of sickling on potassium transport.

9. Hemolytic anemia with impaired hexokinase activity.

10. Estimation of the molecular weights of proteins by Sephadex gel-filtration.

1. Automated oxyhemoglobin dissociation curve construction to assess sickle cell anemia therapy.

2. Antisickling activity of amino acid benzyl esters.

3. Effect of intracellular magnesium and oxygen tension on K+-Cl- cotransport in normal and sickle human red cells.

4. Alternative aspirins as antisickling agents: acetyl-3,5-dibromosalicylic acid.

5. Inhibition of erythrocyte sickling by cystamine, a thiol reagent.

6. Dimethyl adipimidate/Thin film Sample processing (DTS); A simple, low-cost, and versatile nucleic acid extraction assay for downstream analysis.