Literature DB >> 10544162

Infant pulmonary hemorrhage in a suburban home with water damage and mold (Stachybotrys atra).

S M Flappan1, J Portnoy, P Jones, C Barnes.   

Abstract

The American Academy of Pediatrics recently issued guidelines regarding the potential toxic effect of indoor molds. We now report another case of an infant with pulmonary hemorrhage whose residential environmental assessment revealed the presence of the toxigenic mold Stachybotrys atra. We used a questionnaire to identify environmental factors that could predispose the home to fungal contamination. We collected air samples from multiple locations in the home that we felt would reflect areas of relevant exposure. Surface samples were collected with a piece of transparent tape for semiquantitative measurement of spores present. We classified spores into their respective genera based on shape, size, and color. We also measured mycotoxin levels. Air sampling revealed significantly elevated total spore counts in the patient's bedroom and in the attic. Aspergillus/Penicillium species were predominant. Stachybotrys spores were found in the air sampled in the patient's bedroom, as well as from surfaces sampled in the patient's closet and the attic ceiling. Additionally, a small patch of Stachybotrys-contaminated area in the closet ceiling was sent for mycotoxin analysis. This material proved to be highly toxigenic. As the link between the presence of Stachybotrys in the home and pulmonary hemorrhage in infants increases, further efforts should be made to educate physicians, health care providers, and new parents about the potential toxic effects of this mold.

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Year:  1999        PMID: 10544162      PMCID: PMC1566692          DOI: 10.1289/ehp.99107927

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN: 0091-6765            Impact factor:   9.031


  7 in total

1.  Effects of intranasal exposure to spores of Stachybotrys atra in mice.

Authors:  M Nikulin; K Reijula; B B Jarvis; P Veijalainen; E L Hintikka
Journal:  Fundam Appl Toxicol       Date:  1997-02

2.  Experimental lung mycotoxicosis in mice induced by Stachybotrys atra.

Authors:  M Nikulin; K Reijula; B B Jarvis; E L Hintikka
Journal:  Int J Exp Pathol       Date:  1996-10       Impact factor: 1.925

3.  Bacteria, molds, and toxins in water-damaged building materials.

Authors:  M A Andersson; M Nikulin; U Köljalg; M C Andersson; F Rainey; K Reijula; E L Hintikka; M Salkinoja-Salonen
Journal:  Appl Environ Microbiol       Date:  1997-02       Impact factor: 4.792

4.  Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi.

Authors:  R A Etzel; E Montaña; W G Sorenson; G J Kullman; T M Allan; D G Dearborn; D R Olson; B B Jarvis; J D Miller
Journal:  Arch Pediatr Adolesc Med       Date:  1998-08

5.  Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants.

Authors:  B B Jarvis; W G Sorenson; E L Hintikka; M Nikulin; Y Zhou; J Jiang; S Wang; S Hinkley; R A Etzel; D Dearborn
Journal:  Appl Environ Microbiol       Date:  1998-10       Impact factor: 4.792

6.  Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment.

Authors:  E Johanning; R Biagini; D Hull; P Morey; B Jarvis; P Landsbergis
Journal:  Int Arch Occup Environ Health       Date:  1996       Impact factor: 3.015

Review 7.  Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio.

Authors:  D G Dearborn; I Yike; W G Sorenson; M J Miller; R A Etzel
Journal:  Environ Health Perspect       Date:  1999-06       Impact factor: 9.031

  7 in total
  20 in total

1.  Housing standards: a glossary of housing and health.

Authors:  P Howden-Chapman
Journal:  J Epidemiol Community Health       Date:  2004-03       Impact factor: 3.710

2.  A simple polymerase chain reaction/restriction fragment length polymorphism assay capable of identifying medically relevant filamentous fungi.

Authors:  Timothy R Dean; Michael Kohan; Doris Betancourt; Marc Y Menetrez
Journal:  Mol Biotechnol       Date:  2005-09       Impact factor: 2.695

3.  A simple polymerase chain reaction-sequencing analysis capable of identifying multiple medically relevant filamentous fungal species.

Authors:  Timothy R Dean; Michael Kohan; Doris Betancourt; Marc Y Menetrez
Journal:  Mycopathologia       Date:  2006-10       Impact factor: 2.574

4.  Variability of indoor fungal microbiome of green and non-green low-income homes in Cincinnati, Ohio.

Authors:  Kanistha Coombs; Diana Taft; Doyle V Ward; Brett J Green; Ginger L Chew; Behrouz Shamsaei; Jaroslaw Meller; Reshmi Indugula; Tiina Reponen
Journal:  Sci Total Environ       Date:  2017-08-10       Impact factor: 7.963

Review 5.  Indoor air quality, fungi, and health. How do we stand?

Authors:  Norman King; Pierre Auger
Journal:  Can Fam Physician       Date:  2002-02       Impact factor: 3.275

6.  Immunocytochemical localization of stachylysin in Stachybotrys chartarum spores and spore-impacted mouse and rat lung tissue.

Authors:  L Gregory; T G Rand; D Dearborn; I Yike; S Vesper
Journal:  Mycopathologia       Date:  2003       Impact factor: 2.574

7.  Germination, viability and clearance of Stachybotrys chartarum in the lungs of infant rats.

Authors:  Iwona Yike; Stephen Vesper; Joseph F Tomashefski; Dorr G Dearborn
Journal:  Mycopathologia       Date:  2003       Impact factor: 2.574

8.  Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum.

Authors:  Iwona Yike; Martha J Miller; W G Sorenson; Ronald Walenga; Joseph F Tomashefski; Dorr G Dearborn
Journal:  Mycopathologia       Date:  2002       Impact factor: 2.574

9.  Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocystin in carpet dust from damp indoor environments.

Authors:  Steffen Engelhart; Annette Loock; Dirk Skutlarek; Helmut Sagunski; Annette Lommel; Harald Färber; Martin Exner
Journal:  Appl Environ Microbiol       Date:  2002-08       Impact factor: 4.792

10.  Mass spectrometry-based strategy for direct detection and quantification of some mycotoxins produced by Stachybotrys and Aspergillus spp. in indoor environments.

Authors:  Erica Bloom; Karol Bal; Eva Nyman; Aime Must; Lennart Larsson
Journal:  Appl Environ Microbiol       Date:  2007-05-04       Impact factor: 4.792

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