| Literature DB >> 10543898 |
E J Kennelly1, T J Flynn, E P Mazzola, J A Roach, T G McCloud, D E Danford, J M Betz.
Abstract
The novel alkaloid thalictroidine (1), as well as the known alkaloids taspine (2), magnoflorine (3), anagyrine (4), baptifoline (5), 5,6-dehydro-alpha-isolupanine (6), alpha-isolupanine (7), lupanine (8), N-methylcytisine (9), and sparteine (10), were identified from an extract of Caulophyllum thalictroides rhizomes. N-Methylcytisine exhibited teratogenic activity in the rat embryo culture (REC), an in vitro method to detect potential teratogens. The structure of 1 was elucidated using various spectroscopic methods, primarily by NMR techniques. Thalictroidine, anagyrine, and alpha-isolupanine were not teratogenic in the REC at tested concentrations. Taspine (2) showed high embryotoxicity, but no teratogenic activity, in the REC.Entities:
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Year: 1999 PMID： 10543898 DOI： 10.1021/np9901581
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050