Literature DB >> 10543249

Natural killer T cell ligand alpha-galactosylceramide inhibited lymph node metastasis of highly metastatic melanoma cells.

M Nakui1, K Iwakabe, A Ohta, M Sekimoto, M Sato, H Makuuchi, T Kawano, M Taniguchi, T Nishimura.   

Abstract

The role of natural killer T (NKT) cells in the prevention of multiple tumor metastasis was examined. The i.v. inoculation of a highly metastatic subline of B16-BL6 (B16-BL6-HM) melanoma cells resulted in the formation of metastatic nodules in lymph nodes in addition to lung, intrapleural cavity, and ovary. However, treatment of the mice with the NKT cell ligand alpha-galactosylceramide (alpha-GalCer) three times from 1 day after B16-BL6-HM melanoma inoculation caused a significant inhibition of multiple metastasis. Lymph node metastasis of B16-BL6-HM was almost completely blocked by alpha-GalCer treatment. This antimetastatic effect of alpha-GalCer was abolished in NKT cell-deficient mice. These results suggest that alpha-GalCer-activated NKT cells played a critical role in the prevention of lymph node metastasis of melanoma cells.

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Year:  1999        PMID： 10543249      PMCID： PMC5926145          DOI： 10.1111/j.1349-7006.1999.tb00818.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  12 in total

1.  Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12.

Authors:  T Kodama; K Takeda; O Shimozato; Y Hayakawa; M Atsuta; K Kobayashi; M Ito; H Yagita; K Okumura
Journal:  Eur J Immunol       Date:  1999-04       Impact factor: 5.532

2.  Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.

Authors:  T Kawano; J Cui; Y Koezuka; I Toura; Y Kaneko; H Sato; E Kondo; M Harada; H Koseki; T Nakayama; Y Tanaka; M Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

3.  CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.

Authors:  T Kawano; J Cui; Y Koezuka; I Toura; Y Kaneko; K Motoki; H Ueno; R Nakagawa; H Sato; E Kondo; H Koseki; M Taniguchi
Journal:  Science       Date:  1997-11-28       Impact factor: 47.728

4.  Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

Authors:  J Cui; T Shin; T Kawano; H Sato; E Kondo; I Toura; Y Kaneko; H Koseki; M Kanno; M Taniguchi
Journal:  Science       Date:  1997-11-28       Impact factor: 47.728

Review 5.  Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Authors:  G Trinchieri
Journal:  Annu Rev Immunol       Date:  1995       Impact factor: 28.527

Review 6.  The instructive role of innate immunity in the acquired immune response.

Authors:  D T Fearon; R M Locksley
Journal:  Science       Date:  1996-04-05       Impact factor: 47.728

7.  Application of interleukin 12 to antitumor cytokine and gene therapy.

Authors:  T Nishimura; K Watanabe; T Yahata; L Ushaku; K Ando; M Kimura; I Saiki; T Uede; S Habu
Journal:  Cancer Chemother Pharmacol       Date:  1996       Impact factor: 3.333

8.  Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

Authors:  N Burdin; L Brossay; Y Koezuka; S T Smiley; M J Grusby; M Gui; M Taniguchi; K Hayakawa; M Kronenberg
Journal:  J Immunol       Date:  1998-10-01       Impact factor: 5.422

9.  Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice.

Authors:  H Koseki; K Imai; F Nakayama; T Sado; K Moriwaki; M Taniguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

10.  The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells.

Authors:  H Kitamura; K Iwakabe; T Yahata; S Nishimura; A Ohta; Y Ohmi; M Sato; K Takeda; K Okumura; L Van Kaer; T Kawano; M Taniguchi; T Nishimura
Journal:  J Exp Med       Date:  1999-04-05       Impact factor: 14.307
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  5 in total

1.  Potentiation of antitumor effect of NKT cell ligand, alpha-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells.

Authors:  M Nakui; A Ohta; M Sekimoto; M Sato; K Iwakabe; T Yahata; H Kitamura; T Koda; T Kawano; H Makuuchi; M Taniguchi; T Nishimura
Journal:  Clin Exp Metastasis       Date:  2000       Impact factor: 5.150

Review 2.  A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.

Authors:  Sandhya Vasan; Moriya Tsuji
Journal:  Semin Immunol       Date:  2009-12-04       Impact factor: 11.130

3.  Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids.

Authors:  Ya-Jen Chang; Jing-Rong Huang; Yi-Chien Tsai; Jung-Tung Hung; Douglass Wu; Masakazu Fujio; Chi-Huey Wong; Alice L Yu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-12       Impact factor: 11.205

4.  Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.

Authors:  Ryu-Ichiro Hata; Kazuhito Izukuri; Yasumasa Kato; Soichiro Sasaki; Naofumi Mukaida; Yojiro Maehata; Chihiro Miyamoto; Tetsu Akasaka; Xiaoyan Yang; Yoji Nagashima; Kazuyoshi Takeda; Tohru Kiyono; Masaru Taniguchi
Journal:  Sci Rep       Date:  2015-03-13       Impact factor: 4.379

5.  Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T cells.

Authors:  Naoko Mise; Mariko Takami; Akane Suzuki; Toshiko Kamata; Kazuaki Harada; Tomoro Hishiki; Takeshi Saito; Keita Terui; Tetsuya Mitsunaga; Mitsuyuki Nakata; Takayuki Ikeuchi; Toshinori Nakayama; Hideo Yoshida; Shinichiro Motohashi
Journal:  Cancer Sci       Date:  2016-02-09       Impact factor: 6.716
  5 in total

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