Literature DB >> 10542332

Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.

M E Bailey1, B E Albrecht, K J Johnson, M G Darlison.   

Abstract

GABA(C) receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: rho1 (GABRR1), rho2 (GABRR2) and rho3 (GABRR3). We show that GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but that GABRR3 maps to chromosome 3q11-q13.3. Our mapping data suggest that the rho polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10542332     DOI： 10.1016/s0167-4781(99)00167-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

Review 1.  Consequences of the evolution of the GABA(A) receptor gene family.

Authors:  Mark G Darlison; Inderjit Pahal; Christian Thode
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

Review 2.  GABA-ρ receptors: distinctive functions and molecular pharmacology.

Authors:  Moawiah M Naffaa; Sandy Hung; Mary Chebib; Graham A R Johnston; Jane R Hanrahan
Journal:  Br J Pharmacol       Date:  2017-04-12       Impact factor: 8.739

Review 3.  Neurochemicals for the investigation of GABA(C) receptors.

Authors:  Graham A R Johnston; Mary Chebib; Jane R Hanrahan; Kenneth N Mewett
Journal:  Neurochem Res       Date:  2010-10-21       Impact factor: 3.996

4.  trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors.

Authors:  Jimmy Vien; Rujee K Duke; Kenneth N Mewett; Graham A R Johnston; Ryuzo Shingai; Mary Chebib
Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

5.  GABAA receptors in GtoPdb v.2021.3.

Authors:  Delia Belelli; Tim G Hales; Jeremy J Lambert; Bernhard Luscher; Richard Olsen; John A Peters; Uwe Rudolph; Werner Sieghart
Journal:  IUPHAR BPS Guide Pharm CITE       Date:  2021-09-02

6.  Expression of gamma-aminobutyric acid rho 1 and rho 1 Delta 450 as gene fusions with the green fluorescent protein.

Authors:  A Martinez-Torres; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205

7.  An Update on GABAρ Receptors.

Authors:  Gustavo Martínez-Delgado; Argel Estrada-Mondragón; Ricardo Miledi; Ataúlfo Martínez-Torres
Journal:  Curr Neuropharmacol       Date:  2010-12       Impact factor: 7.363

8.  Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism.

Authors:  Moawiah M Naffaa; Nathan Absalom; V Raja Solomon; Mary Chebib; David E Hibbs; Jane R Hanrahan
Journal:  PLoS One       Date:  2016-05-31       Impact factor: 3.240

9.  Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury.

Authors:  Meinrad Drexel; Noora Puhakka; Elke Kirchmair; Heide Hörtnagl; Asla Pitkänen; Günther Sperk
Journal:  Neuropharmacology       Date:  2014-09-16       Impact factor: 5.250
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.