Literature DB >> 10542083

Training ribozymes to switch.

K A Marshall1, A D Ellington.   

Abstract

Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes are specifically activated by a factor of 5,000 - the largest allosteric ribozyme activation by a small molecule seen to date.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10542083     DOI： 10.1038/14872

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  6 in total

1.  Identification of dynamical hinge points of the L1 ligase molecular switch.

Authors:  George M Giambasu; Tai-Sung Lee; Carlos P Sosa; Michael P Robertson; William G Scott; Darrin M York
Journal:  RNA       Date:  2010-02-18       Impact factor: 4.942

2.  Mapping L1 ligase ribozyme conformational switch.

Authors:  George M Giambaşu; Tai-Sung Lee; William G Scott; Darrin M York
Journal:  J Mol Biol       Date:  2012-07-03       Impact factor: 5.469

3.  Coupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.

Authors:  Ravi Radhakrishnan
Journal:  Biophys J       Date:  2007-06-01       Impact factor: 4.033

4.  Engineered allosteric ribozymes that sense the bacterial second messenger cyclic diguanosyl 5'-monophosphate.

Authors:  Hongzhou Gu; Kazuhiro Furukawa; Ronald R Breaker
Journal:  Anal Chem       Date:  2012-05-21       Impact factor: 6.986

5.  Group I aptazymes as genetic regulatory switches.

Authors:  Kristin M Thompson; Heather A Syrett; Scott M Knudsen; Andrew D Ellington
Journal:  BMC Biotechnol       Date:  2002-12-04       Impact factor: 2.563

Review 6.  Modulating RNA structure and catalysis: lessons from small cleaving ribozymes.

Authors:  Cedric Reymond; Jean-Denis Beaudoin; Jean-Pierre Perreault
Journal:  Cell Mol Life Sci       Date:  2009-08-30       Impact factor: 9.261
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.