Literature DB >> 10537020

Age-related defects in lifespan and learning ability in SAMP8 mice.

Y Nomura1, Y Okuma.   

Abstract

Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAMP8 mice have age-related defects in learning and cognitive abilities. We review recent findings on alterations in SAMP8 brain in neurochemical parameters related to neurotransmission and synaptic plasticity compared to those in SAMR1 brain as the control. In addition, we report the preventive effects of drugs on learning deficiencies in SAMP8 and discuss the usefulness of SAMP8 as an animal model of age-related learning deficiencies.

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Year:  1999        PMID： 10537020     DOI： 10.1016/s0197-4580(99)00006-8

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  22 in total

1.  Early postnatal sound exposure induces lasting neuronal changes in the inferior colliculus of senescence accelerated mice (SAMP8): a morphometric study on GABAergic neurons and NMDA expression.

Authors:  Dietrich Ernst Lorke; Lai Yung Wong; Helen W L Lai; Paul W F Poon; Aiqun Zhang; Wood Yee Chan; David Tai Wai Yew
Journal:  Cell Mol Neurobiol       Date:  2003-04       Impact factor: 5.046

2.  Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.

Authors:  Wayne Chadwick; Yu Zhou; Sung-Soo Park; Liyun Wang; Nicholas Mitchell; Matthew D Stone; Kevin G Becker; Bronwen Martin; Stuart Maudsley
Journal:  PLoS One       Date:  2010-12-17       Impact factor: 3.240

3.  Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody.

Authors:  David Frescas; Christelle M Roux; Semra Aygun-Sunar; Anatoli S Gleiberman; Peter Krasnov; Oleg V Kurnasov; Evguenia Strom; Lauren P Virtuoso; Michelle Wrobel; Andrei L Osterman; Marina P Antoch; Vadim Mett; Olga B Chernova; Andrei V Gudkov
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-13       Impact factor: 11.205

4.  Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain.

Authors:  Sergi Bayod; Carolina Guzmán-Brambila; Sandra Sanchez-Roige; Jaume F Lalanza; Perla Kaliman; Daniel Ortuño-Sahagun; Rosa M Escorihuela; Mercè Pallàs
Journal:  J Mol Neurosci       Date:  2014-07-16       Impact factor: 3.444

5.  A novel cyclic peptide (Naturido) modulates glia-neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice.

Authors:  Shinichi Ishiguro; Tetsuro Shinada; Zhou Wu; Mayumi Karimazawa; Michimasa Uchidate; Eiji Nishimura; Yoko Yasuno; Makiko Ebata; Piyamas Sillapakong; Hiromi Ishiguro; Nobuyoshi Ebata; Junjun Ni; Muzhou Jiang; Masanobu Goryo; Keishi Otsu; Hidemitsu Harada; Koichi Suzuki
Journal:  PLoS One       Date:  2021-01-27       Impact factor: 3.240

6.  Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8).

Authors:  Christian Griñan-Ferré; David Pérez-Cáceres; Sofía Martínez Gutiérrez-Zetina; Antoni Camins; Verónica Palomera-Avalos; Daniel Ortuño-Sahagún; M Teresa Rodrigo; M Pallàs
Journal:  Mol Neurobiol       Date:  2015-05-27       Impact factor: 5.590

7.  Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model.

Authors:  Hualong Wang; Kaoqi Lian; Bing Han; Yanyong Wang; Sheng-Han Kuo; Yuan Geng; Jing Qiang; Meiyu Sun; Mingwei Wang
Journal:  J Alzheimers Dis       Date:  2014       Impact factor: 4.472

8.  Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice.

Authors:  Gemma Manich; Jaume del Valle; Itsaso Cabezón; Antoni Camins; Mercè Pallàs; Carme Pelegrí; Jordi Vilaplana
Journal:  Age (Dordr)       Date:  2013-07-19

Review 9.  The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model.

Authors:  Yoichi Chiba; Atsuyoshi Shimada; Naoko Kumagai; Keisuke Yoshikawa; Sanae Ishii; Ayako Furukawa; Shiro Takei; Masaaki Sakura; Noriko Kawamura; Masanori Hosokawa
Journal:  Neurochem Res       Date:  2008-08-08       Impact factor: 3.996

10.  A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes.

Authors:  Amy E Perkins; Tamara L Doremus-Fitzwater; Robert L Spencer; Elena I Varlinskaya; Melissa M Conti; Christopher Bishop; Terrence Deak
Journal:  Exp Gerontol       Date:  2016-01-23       Impact factor: 4.032
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