| Literature DB >> 10536276 |
Y Mitsui1, K Okamoto, D P Martin, J D Schmelzer, P A Low.
Abstract
We evaluated the proinflammatory cytokines, TNF-alpha and IL-1beta, mRNA expression in the rat sciatic and tibial nerves following ischemia-reperfusion (IR) injury, using competitive RT-PCR, to explore the role of cytokines in IR injury. The expressions of both TNF-alpha and IL-1beta mRNA were related to severity of ischemia and occurred with reperfusion rather than ischemia alone. TNF-alpha gene expression peaked at 24 h of reperfusion, while that of IL-1beta peaked at 12 h. These data support the notion that the proinflammatory cytokines TNF-alpha and IL-1beta are involved in the inflammatory response of IR injury to the peripheral nervous system and may be involved in the pathophysiology of ischemic fiber degeneration.Entities:
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Year: 1999 PMID： 10536276 DOI： 10.1016/s0006-8993(99)01830-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252