Literature DB >> 10536190

In vitro antitumour activity and cellular pharmacological properties of the platinum-iminoether complex trans-[PtCl2[E-HN=C(OMe)Me]2].

M Coluccia1, A Nassi, A Boccarelli, D Giordano, N Cardellicchio, F P Intini, G Natile, A Barletta, A Paradiso.   

Abstract

The platinum complex trans-[PtCl2¿E-HN=C(OMe)Me¿2] was compared to cisplatin for cytotoxicity towards tumour cells, and for cellular pharmacological properties in A2780 and cisplatin-resistant A2780/Cp8 ovarian cancer cells. Trans-[PtCl2¿E-HN=C(OMe)Me¿2] was comparably cytotoxic to cisplatin (mean IC50 after 72 h exposure = 6. 1 microM and 7 microM, respectively) and did not show cross-resistance in A2780/Cp8 cells (resistance factor = 0.9). Cellular accumulation measurements after treatment with equimolar drug concentrations showed that trans-[PtCl2¿E-HN=C(OMe)Me¿2] entered both A2780 and A2780/Cp8 cells much more efficiently than cisplatin, whose accumulation was reduced in A2780/Cp8 cells. Unlike cisplatin, trans-[PtCl2¿E-HN=C(OMe)Me¿2] induced rapidly cell death and cell cycle modifications of treated cells, thus indicating substantially different mechanistic properties.

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Year:  1999        PMID： 10536190     DOI： 10.3892/ijo.15.5.1039

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  6 in total

1.  Synthesis, characterization, and biological activity of platinum II, III, and IV pivaloamidine complexes.

Authors:  Marilù Sinisi; Valentina Gandin; Teresa Saltarella; Francesco P Intini; Concetta Pacifico; Christine Marzano; Giovanni Natile
Journal:  J Biol Inorg Chem       Date:  2014-05-22       Impact factor: 3.358

Review 2.  The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.

Authors:  Timothy C Johnstone; Kogularamanan Suntharalingam; Stephen J Lippard
Journal:  Chem Rev       Date:  2016-02-11       Impact factor: 60.622

3.  DNA-protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes.

Authors:  Olga Novakova; Jana Kasparkova; Jaroslav Malina; Giovanni Natile; Viktor Brabec
Journal:  Nucleic Acids Res       Date:  2003-11-15       Impact factor: 16.971

4.  Solution behaviour and biological activity of bisamidine complexes of platinum(II).

Authors:  C Marzano; S Mazzega Sbovata; F Bettio; R A Michelin; R Seraglia; T Kiss; A Venzo; R Bertani
Journal:  J Biol Inorg Chem       Date:  2007-01-09       Impact factor: 3.862

5.  New Dihydro OO'Bis(Salicylidene) 2,2' Aminobenzothiazolyl Borate Complexes: Kinetic and Voltammetric Studies of Dimethyltin Copper Complex with Guanine, Adenine, and Calf Thymus DNA.

Authors:  Farukh Arjmand; Bhawana Mohani; Shamima Parveen
Journal:  Bioinorg Chem Appl       Date:  2006-03-05       Impact factor: 7.778

6.  Trans-platinum(II) complexes with cyclohexylamine as expectator ligand induce necrosis in tumour cells by inhibiting DNA synthesis and RNA transcription.

Authors:  V Cepero; B García-Serrelde; V Moneo; F Blanco; A M González-Vadillo; A Alvarez-Valdés; C Navarro-Ranninger; A Carnero
Journal:  Clin Transl Oncol       Date:  2007-08       Impact factor: 3.340
  6 in total

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