BACKGROUND: The aim of this study was to test an association between alleles of the alpha(2A)-adrenoceptor gene with hereditary hypertension and with alterations of lipid and carbohydrate metabolism. METHODS: Genomic DNA was isolated from 147 hypertensive patients and digested with DraI. Genotypes at the alpha(2A)-adrenoceptor were identified by restriction fragment length polymorphism. Genotype at each locus was related to blood pressure, family history of hypertension and various clinical chemistry parameters. RESULTS: The alpha(2A)-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. Patients with the d allele of the alpha(2A)-adrenoceptor had significantly lower HbA(1) (5.6 vs 6.2%, P=0.0344) and HbA(1c) (3.4 vs 3.9%, P=0.0237) and total cholesterol (212 vs 229 mg/dl, P=0.0333) than those without. Similar trends, which failed to reach statistical significance, were seen for glucose, triglycerides and LDL cholesterol. CONCLUSIONS: We propose that alleles at the alpha(2A)-adrenoceptor locus might contribute to interindividual differences in the regulation of human lipid and glucose metabolism.
BACKGROUND: The aim of this study was to test an association between alleles of the alpha(2A)-adrenoceptor gene with hereditary hypertension and with alterations of lipid and carbohydrate metabolism. METHODS: Genomic DNA was isolated from 147 hypertensivepatients and digested with DraI. Genotypes at the alpha(2A)-adrenoceptor were identified by restriction fragment length polymorphism. Genotype at each locus was related to blood pressure, family history of hypertension and various clinical chemistry parameters. RESULTS: The alpha(2A)-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. Patients with the d allele of the alpha(2A)-adrenoceptor had significantly lower HbA(1) (5.6 vs 6.2%, P=0.0344) and HbA(1c) (3.4 vs 3.9%, P=0.0237) and total cholesterol (212 vs 229 mg/dl, P=0.0333) than those without. Similar trends, which failed to reach statistical significance, were seen for glucose, triglycerides and LDL cholesterol. CONCLUSIONS: We propose that alleles at the alpha(2A)-adrenoceptor locus might contribute to interindividual differences in the regulation of humanlipid and glucose metabolism.
Authors: Kersten M Small; Kari M Brown; Carrie A Seman; Cheryl T Theiss; Stephen B Liggett Journal: Proc Natl Acad Sci U S A Date: 2006-03-27 Impact factor: 11.205
Authors: Daniel Kurnik; Mordechai Muszkat; Chun Li; Gbenga G Sofowora; Eitan A Friedman; Mika Scheinin; Alastair J J Wood; C Michael Stein Journal: Circ Cardiovasc Genet Date: 2011-02-15