| Literature DB >> 10534277 |
A J Slooter1, M Cruts, A Ott, M L Bots, J C Witteman, A Hofman, C Van Broeckhoven, M M Breteler, C M van Duijn.
Abstract
The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-epsilon4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.Entities:
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Year: 1999 PMID： 10534277 DOI： 10.1212/wnl.53.7.1593
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910