Literature DB >> 10531478

Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A.

G S Crowhurst1, A R Dalby, M N Isupov, J W Campbell, J A Littlechild.   

Abstract

The crystal structure of the tetrameric glycolytic enzyme phosphoglycerate mutase from the yeast Saccharomyces cerevisiae has been determined to 1.7 A resolution in complex with the sugar substrate. The difference map indicates that 3-phosphoglycerate is bound at the base of a 12 A cleft, positioning C2 of the substrate within 3.5 A of the primary catalytic residue, histidine 8.

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Year:  1999        PMID： 10531478     DOI： 10.1107/s0907444999009944

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  4 in total

1.  Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase.

Authors:  Harriet A Watkins; Edward N Baker
Journal:  J Bacteriol       Date:  2006-05       Impact factor: 3.490

2.  Unliganded structure of human bisphosphoglycerate mutase reveals side-chain movements induced by ligand binding.

Authors:  A Patterson; N C Price; J Nairn
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-10-27

3.  An ensemble of structures of Burkholderia pseudomallei 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase.

Authors:  Douglas R Davies; Bart L Staker; Jan A Abendroth; Thomas E Edwards; Robert Hartley; Jess Leonard; Hidong Kim; Amanda L Rychel; Stephen N Hewitt; Peter J Myler; Lance J Stewart
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-08-13

4.  Molecular dynamics simulation reveals how phosphorylation of tyrosine 26 of phosphoglycerate mutase 1 upregulates glycolysis and promotes tumor growth.

Authors:  Yan Wang; Wen-Sheng Cai; Luonan Chen; Guanyu Wang
Journal:  Oncotarget       Date:  2017-02-14
  4 in total

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