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Literature DB >> 10531291

Inhibition of neutrophil apoptosis by verotoxin 2 derived from Escherichia coli O157:H7.

J Liu¹, T Akahoshi, T Sasahana, H Kitasato, R Namai, T Sasaki, M Inoue, H Kondo.

Abstract

In order to evaluate the pathological role of verotoxin 2 (VT2), we investigated the effects of VT2 on neutrophil apoptosis in vitro. The results showed that VT2 caused a significant delay in spontaneous neutrophil apoptosis and that the effect was abrogated by a protein kinase C inhibitor. These data indicate that longer survival of neutrophils may aggravate neutrophil-mediated tissue damage in VT2-associated diseases.

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Year: 1999 PMID： 10531291 PMCID： PMC97017

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

19 in total

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