Literature DB >> 10531062

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.

S L Stroschein1, W Wang, S Zhou, Q Zhou, K Luo.   

Abstract

Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling to regulate cell growth and differentiation. The SnoN oncoprotein was found to interact with Smad2 and Smad4 and to repress their abilities to activate transcription through recruitment of the transcriptional corepressor N-CoR. Immediately after TGF-beta stimulation, SnoN is rapidly degraded by the nuclear accumulation of Smad3, allowing the activation of TGF-beta target genes. By 2 hours, TGF-beta induces a marked increase in SnoN expression, resulting in termination of Smad-mediated transactivation. Thus, SnoN maintains the repressed state of TGF-beta-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling.

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Year:  1999        PMID： 10531062     DOI： 10.1126/science.286.5440.771

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  153 in total

1.  Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

Authors:  W Wang; F V Mariani; R M Harland; K Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

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Journal:  EMBO J       Date:  2000-04-17       Impact factor: 11.598

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Authors:  D Liu; B L Black; R Derynck
Journal:  Genes Dev       Date:  2001-11-15       Impact factor: 11.361

4.  Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.

Authors:  S L Stroschein; S Bonni; J L Wrana; K Luo
Journal:  Genes Dev       Date:  2001-11-01       Impact factor: 11.361

5.  The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.

Authors:  Emilia Solomon; Hui Li; Sara Duhachek Muggy; Emilia Syta; Anna Zolkiewska
Journal:  J Biol Chem       Date:  2010-05-10       Impact factor: 5.157

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Authors:  C Dou; J Lee; B Liu; F Liu; J Massague; S Xuan; E Lai
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

7.  Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.

Authors:  H Kaji; L Canaff; J J Lebrun; D Goltzman; G N Hendy
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

8.  Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.

Authors:  M Fukuchi; T Imamura; T Chiba; T Ebisawa; M Kawabata; K Tanaka; K Miyazono
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

9.  Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4.

Authors:  Aryeh Warmflash; Qixiang Zhang; Benoit Sorre; Alin Vonica; Eric D Siggia; Ali H Brivanlou
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-11       Impact factor: 11.205

10.  ZAS3 accentuates transforming growth factor β signaling in epithelial cells.

Authors:  Adam J Yakovich; Bo Jiang; Carl E Allen; Jianguo Du; Lai-Chu Wu; John A Barnard
Journal:  Cell Signal       Date:  2010-08-21       Impact factor: 4.315
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