| Literature DB >> 10530960 |
H B Mereyala1, R R Gadikota, M Joe, S K Arora, S G Dastidar, S Agarwal.
Abstract
Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.Entities:
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Year: 1999 PMID： 10530960 DOI： 10.1016/s0968-0896(99)00164-9
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641