| Literature DB >> 10530780 |
T Yanagawa1, T Ishikawa, T Ishii, K Tabuchi, S Iwasa, S Bannai, K Omura, H Suzuki, H Yoshida.
Abstract
Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P = 0.00005) and thyroiditis group (P = 0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance. Immunohistochemistry indicated that Prx I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10530780 DOI： 10.1016/s0304-3835(99)00243-8
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679