S Patra1, S C Samal, A Chacko, V I Mathan, M M Mathan. 1. Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore, Tamilnadu, India. wususama@hotmail.com
Abstract
BACKGROUND: Current interest in cytomegalovirus (CMV) is largely due to an increase in the number of cases of acquired immunodeficiency syndrome and organ transplantation in recent years. The proper recognition of CMV-infected cells in gastrointestinal mucosal biopsies is critical for effective treatment of this condition. METHODS: A total of 6580 endoscopic mucosal biopsies from 6323 patients in the 8-year period (1989-1996) were examined for CMV inclusion bodies. The endoscopic appearance and particularly the presence of ulcers were also analysed. RESULTS AND CONCLUSIONS: The prevalence of cytomegalovirus (CMV) inclusions was 9 per thousand in the gastrointestinal mucosal biopsies from an unselected group of patients. Of the 54 patients with CMV infection, 37 were immunocompromised and 17 apparently immunocompetent. Typical Cowdry inclusions and atypical inclusions were present, the latter more frequently in immunocompromised patients. The maximum prevalence of inclusions was in the oesophageal mucosa in immunocompromised individuals.
BACKGROUND: Current interest in cytomegalovirus (CMV) is largely due to an increase in the number of cases of acquired immunodeficiency syndrome and organ transplantation in recent years. The proper recognition of CMV-infected cells in gastrointestinal mucosal biopsies is critical for effective treatment of this condition. METHODS: A total of 6580 endoscopic mucosal biopsies from 6323 patients in the 8-year period (1989-1996) were examined for CMV inclusion bodies. The endoscopic appearance and particularly the presence of ulcers were also analysed. RESULTS AND CONCLUSIONS: The prevalence of cytomegalovirus (CMV) inclusions was 9 per thousand in the gastrointestinal mucosal biopsies from an unselected group of patients. Of the 54 patients with CMV infection, 37 were immunocompromised and 17 apparently immunocompetent. Typical Cowdry inclusions and atypical inclusions were present, the latter more frequently in immunocompromised patients. The maximum prevalence of inclusions was in the oesophageal mucosa in immunocompromised individuals.
Authors: Pedro Hf Amaral; Bernadete Mc Ferreira; Sergio Roll; Precil Dmm Neves; Luca Ga Pivetta; Sara Mohrbacher; Eduardo Rm Dias; Victor Ah Sato; Érico S Oliveira; Leonardo Vb Pereira; Alessandra M Bales; Luciana L Nardotto; Jéssica N Ferreira; Américo L Cuvello-Neto; Pedro R Chocair Journal: Eur J Case Rep Intern Med Date: 2020-09-02
Authors: Franck Halary; Vincent Pitard; Dorota Dlubek; Roman Krzysiek; Henri de la Salle; Pierre Merville; Claire Dromer; Dominique Emilie; Jean-François Moreau; Julie Déchanet-Merville Journal: J Exp Med Date: 2005-05-16 Impact factor: 14.307