K Sugiura1, Y Muro. 1. Department of Dermatology, Nagoya University School of Medicine, Japan.
Abstract
OBJECTIVE: To elucidate the frequency and clinical significance of anti-annexin V antibodies in patients with scleroderma. METHODS: The study population consisted of 66 patients with scleroderma. Their sera were examined for IgG anti-annexin V antibodies by ELISA and immunoblotting. RESULTS: IgG anti-annexin V antibodies were detected by ELISA in 12 patients (18.2%) with scleroderma. Anti-annexin V antibodies were associated with digital ischemia in the patients with scleroderma. Only one patient of the 12 had anticardiolipin antibodies. Although 6 patients with anti-annexin V antibodies were also examined for activated partial thromboplastin time (APTT), none showed prolonged APTT. No IgG anti-annexin V antibodies were detected by immunoblotting. CONCLUSION: Anti-annexin V antibodies in scleroderma are related to digital ischemia. These antibodies may be associated with the pathogenesis of vascular involvement in scleroderma.
OBJECTIVE: To elucidate the frequency and clinical significance of anti-annexin V antibodies in patients with scleroderma. METHODS: The study population consisted of 66 patients with scleroderma. Their sera were examined for IgG anti-annexin V antibodies by ELISA and immunoblotting. RESULTS: IgG anti-annexin V antibodies were detected by ELISA in 12 patients (18.2%) with scleroderma. Anti-annexin V antibodies were associated with digital ischemia in the patients with scleroderma. Only one patient of the 12 had anticardiolipin antibodies. Although 6 patients with anti-annexin V antibodies were also examined for activated partial thromboplastin time (APTT), none showed prolonged APTT. No IgG anti-annexin V antibodies were detected by immunoblotting. CONCLUSION: Anti-annexin V antibodies in scleroderma are related to digital ischemia. These antibodies may be associated with the pathogenesis of vascular involvement in scleroderma.
Authors: Reem A Habeeb; Howaida E Mansour; Aya M Abdeldayem; Rania A Abo-Shady; Iman A Hassan; Nazek K Saafan; Dalia G Aly Journal: Clin Med Insights Arthritis Musculoskelet Disord Date: 2010-04-28