| Literature DB >> 10527830 |
S Breun1, B Salmons, W H Günzburg, J G Baumann.
Abstract
Murine cell-derived MLV vector particles usually are highly sensitive to human complement-mediated lysis. Expression of the human complement inhibitor CD59 on murine packaging cells resulted in partial protection of these cells from lysis caused by human complement proteins. Furthermore, CD59 was incorporated into MLV vector particles released by these packaging cells, leading to an improved resistance of the virions against human complement-mediated inactivation. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 10527830 DOI： 10.1006/bbrc.1999.1474
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575