Literature DB >> 10527456

Immunocytochemical localization of cPLA2 in rat and monkey spinal cord.

W Y Ong1, L A Horrocks, A A Farooqui.   

Abstract

Rat spinal cord contains a high level of calcium-dependent cytosolic phospholipase A2 (PLA2) activity. A dense immunoreactivity is present in motor neurons from cervical, thoracic, lumbar, and sacral regions of rat spinal cord. Under normal conditions, this enzyme liberates arachidonic acid, a polyunsaturated fatty acid that is a second messenger itself, and a precursor for eicosanoids. However, under pathological conditions during spinal cord injury, intracellular calcium increases so the cytosolic PLA2 may also be involved in the release and accumulation of arachidonic acid, eicosanoids, and lipid peroxides.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10527456     DOI： 10.1007/BF02736926

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  21 in total

1.  A cytoarchitectonic atlas of the spinal cord in the cat.

Authors:  B REXED
Journal:  J Comp Neurol       Date:  1954-04       Impact factor: 3.215

2.  A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesions.

Authors:  T L Sandhya; W Y Ong; L A Horrocks; A A Farooqui
Journal:  Brain Res       Date:  1998-03-30       Impact factor: 3.252

3.  Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain.

Authors:  D T Stephenson; C A Lemere; D J Selkoe; J A Clemens
Journal:  Neurobiol Dis       Date:  1996-02       Impact factor: 5.996

Review 4.  Cytosolic phospholipase A2.

Authors:  J D Clark; A R Schievella; E A Nalefski; L L Lin
Journal:  J Lipid Mediat Cell Signal       Date:  1995-10

Review 5.  Involvement of phospholipase A2 in neurodegeneration.

Authors:  A A Farooqui; H C Yang; L Horrocks
Journal:  Neurochem Int       Date:  1997-06       Impact factor: 3.921

6.  Calcium-sensitive cytosolic phospholipase A2 (cPLA2) is expressed in human brain astrocytes.

Authors:  D T Stephenson; J V Manetta; D L White; X G Chiou; L Cox; B Gitter; P C May; J D Sharp; R M Kramer; J A Clemens
Journal:  Brain Res       Date:  1994-02-21       Impact factor: 3.252

7.  Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.

Authors:  D S Koh; J R Geiger; P Jonas; B Sakmann
Journal:  J Physiol       Date:  1995-06-01       Impact factor: 5.182

8.  Activation of ethanolamine phospholipase A2 in Brain during ischemia.

Authors:  A D Edgar; J Strosznajder; L A Horrocks
Journal:  J Neurochem       Date:  1982-10       Impact factor: 5.372

9.  Coexpression of phospholipase A2 isoforms in rat striatal astrocytes.

Authors:  P Zanassi; M Paolillo; S Schinelli
Journal:  Neurosci Lett       Date:  1998-05-15       Impact factor: 3.046

10.  Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.

Authors:  J A Clemens; D T Stephenson; E B Smalstig; E F Roberts; E M Johnstone; J D Sharp; S P Little; R M Kramer
Journal:  Stroke       Date:  1996-03       Impact factor: 7.914
View more
  10 in total

1.  Selective activation of microglia facilitates synaptic strength.

Authors:  Anna K Clark; Doris Gruber-Schoffnegger; Ruth Drdla-Schutting; Katharina J Gerhold; Marzia Malcangio; Jürgen Sandkühler
Journal:  J Neurosci       Date:  2015-03-18       Impact factor: 6.167

2.  Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor.

Authors:  Yuanyi Wang; Zhongwen Gao; Yiping Zhang; Shi-Qing Feng; Yulong Liu; Lisa B E Shields; Ying-Zheng Zhao; Qingsan Zhu; David Gozal; Christopher B Shields; Jun Cai
Journal:  Mol Neurobiol       Date:  2015-06-18       Impact factor: 5.590

3.  Characterizing phospholipase A2-induced spinal cord injury-a comparison with contusive spinal cord injury in adult rats.

Authors:  Nai-Kui Liu; William Lee Titsworth; Yi Ping Zhang; Aurela I Xhafa; Christopher B Shields; Xiao-Ming Xu
Journal:  Transl Stroke Res       Date:  2011-12-01       Impact factor: 6.829

4.  Imaging apomorphine stimulation of brain arachidonic acid signaling via D2-like receptors in unanesthetized rats.

Authors:  Abesh Kumar Bhattacharjee; Lisa Chang; Laura White; Richard P Bazinet; Stanley I Rapoport
Journal:  Psychopharmacology (Berl)       Date:  2008-02-15       Impact factor: 4.530

5.  Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia.

Authors:  D H Kim; B Fitzsimmons; M P Hefferan; C I Svensson; E Wancewicz; B P Monia; G Hung; M Butler; M Marsala; X-Y Hua; T L Yaksh
Journal:  Neuroscience       Date:  2008-04-30       Impact factor: 3.590

Review 6.  Phospholipase A2 and its molecular mechanism after spinal cord injury.

Authors:  Nai-Kui Liu; Xiao-Ming Xu
Journal:  Mol Neurobiol       Date:  2010-02-03       Impact factor: 5.682

7.  Epidural dexamethasone decreased inflammatory hyperalgesia and spinal cPLA₂ expression in a rat formalin test.

Authors:  Sam-Hong Min; Jung-Sub Soh; Ji-Yong Park; Sung-Uk Choi; Hye-Won Lee; Jae-Jin Lee; Jae-Hwan Kim
Journal:  Yonsei Med J       Date:  2014-11       Impact factor: 2.759

8.  Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth.

Authors:  Christabel Fung-Yih Ho; Nadia Binte Ismail; Joled Kong-Ze Koh; Saravanan Gunaseelan; Yi-Hua Low; Yee-Kong Ng; John Jia-En Chua; Wei-Yi Ong
Journal:  Neurochem Res       Date:  2018-06-13       Impact factor: 3.996

Review 9.  Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma.

Authors:  Hao-Jie Zhang; Yi-Tuo Chen; Xin-Li Hu; Wan-Ta Cai; Xiang-Yang Wang; Wen-Fei Ni; Kai-Liang Zhou
Journal:  Neural Regen Res       Date:  2023-02       Impact factor: 6.058

10.  Phospholipase A2 Inhibitor-Loaded Phospholipid Micelles Abolish Neuropathic Pain.

Authors:  Sonia Kartha; Lesan Yan; Meagan E Ita; Ahmad Amirshaghaghi; Lijun Luo; Yulong Wei; Andrew Tsourkas; Beth A Winkelstein; Zhiliang Cheng
Journal:  ACS Nano       Date:  2020-06-04       Impact factor: 15.881
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.