RATIONALE: A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE: To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of >600 carefully screened normals tested over the past 12 years was completed. RESULTS: Male>female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers. CONCLUSIONS: Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.
RATIONALE: A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE: To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI, rather than simple sex differences in the regulation of PPI. A retrospective analyses of >600 carefully screened normals tested over the past 12 years was completed. RESULTS: Male>female acoustic PPI was detected in analyses that included: 1) all subjects; or 2) self-declared non-smokers. CONCLUSIONS: Sex differences in PPI cannot be accounted for by smoking history, because they are present across a large sample of non-smoking normal controls.
Authors: L A Kilpatrick; E Ornitz; H Ibrahimovic; M Treanor; M Craske; M Nazarian; J S Labus; E A Mayer; B D Naliboff Journal: Biol Psychol Date: 2010-03-01 Impact factor: 3.251
Authors: Scott R Vrana; Patrick S Calhoun; F Joseph McClernon; Michelle F Dennis; Sherman T Lee; Jean C Beckham Journal: Psychopharmacology (Berl) Date: 2013-07-05 Impact factor: 4.530
Authors: David Hessl; Elizabeth Berry-Kravis; Lisa Cordeiro; Jennifer Yuhas; Edward M Ornitz; Aaron Campbell; Elizabeth Chruscinski; Crystal Hervey; James M Long; Randi J Hagerman Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-06-05 Impact factor: 3.568