Literature DB >> 10525481

An introduction to the pathophysiology of osteoarthritis.

A R Poole1.   

Abstract

Osteoarthritis involves the degeneration of articular cartilage together with changes in subchondral bone and limited intra-articular inflammation. In this chapter these changes are reviewed at the tissue, cell and molecular levels to reveal the complexity of a process which involves multiple changes in joint structure and turnover.

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Year:  1999        PMID： 10525481     DOI： 10.2741/poole

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  57 in total

1.  Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.

Authors:  Anja Weimer; Henning Madry; Jagadeesh K Venkatesan; Gertrud Schmitt; Janina Frisch; Anna Wezel; Jochen Jung; Dieter Kohn; Ernest F Terwilliger; Stephen B Trippel; Magali Cucchiarini
Journal:  Mol Med       Date:  2012-05-09       Impact factor: 6.354

2.  2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin pathway in rabbit articular chondrocytes.

Authors:  Seon Mi Yu; Hyun Ah Kim; Song-Ja Kim
Journal:  Exp Mol Med       Date:  2010-07-31       Impact factor: 8.718

3.  Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography.

Authors:  D D McErlain; C T G Appleton; R B Litchfield; V Pitelka; J L Henry; S M Bernier; F Beier; D W Holdsworth
Journal:  Osteoarthritis Cartilage       Date:  2007-09-27       Impact factor: 6.576

4.  Nanomedicine: AFM tackles osteoarthritis.

Authors:  Thomas Aigner; Nicole Schmitz; Jochen Haag
Journal:  Nat Nanotechnol       Date:  2009-03       Impact factor: 39.213

Review 5.  MR imaging of articular cartilage physiology.

Authors:  Jung-Ah Choi; Garry E Gold
Journal:  Magn Reson Imaging Clin N Am       Date:  2011-05       Impact factor: 2.266

6.  Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.

Authors:  Q Chu; M Lopez; K Hayashi; M Ionescu; R C Billinghurst; K A Johnson; A R Poole; M D Markel
Journal:  Osteoarthritis Cartilage       Date:  2002-08       Impact factor: 6.576

7.  Genetic polymorphism of PITX1 in susceptibility to knee osteoarthritis in a Chinese Han population: a case-control study.

Authors:  Jianbo Fan; Dongquan Shi; Jin Dai; Lunqing Zhu; Jianghui Qin; Zhenxing Shao; Xusheng Qiu; Zhihong Xu; Dongyang Chen; Qing Jiang
Journal:  Rheumatol Int       Date:  2010-01-07       Impact factor: 2.631

8.  IL-1beta suppresses the formation of osteoclasts by increasing OPG production via an autocrine mechanism involving celecoxib-related prostaglandins in chondrocytes.

Authors:  Yusuke Watanabe; Aki Namba; Yukiko Aida; Kazuhiro Honda; Hideki Tanaka; Naoto Suzuki; Hideo Matsumura; Masao Maeno
Journal:  Mediators Inflamm       Date:  2010-02-24       Impact factor: 4.711

9.  Expression of collagen type I and type II in consecutive stages of human osteoarthritis.

Authors:  Nicolai Miosge; Michael Hartmann; Cyrilla Maelicke; Rainer Herken
Journal:  Histochem Cell Biol       Date:  2004-08-17       Impact factor: 4.304

10.  Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study.

Authors:  Janny C de Grauw; Chris H A van de Lest; Paul René van Weeren
Journal:  Arthritis Res Ther       Date:  2009-03-09       Impact factor: 5.156
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