| Literature DB >> 10525310 |
M H Xie1, I Holcomb, B Deuel, P Dowd, A Huang, A Vagts, J Foster, J Liang, J Brush, Q Gu, K Hillan, A Goddard, A L Gurney.
Abstract
We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 10525310 DOI： 10.1006/cyto.1999.0485
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861