OBJECTIVE: To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections. METHODS: MBL alleles and serum concentrations were determined by polymerase chain reaction and enzyme-linked immunosorbent assay, respectively, in 91 Danish patients with SLE and in 250 controls. RESULTS: Homozygosity for MBL variant alleles was observed in 7.7% of the SLE patients compared with 2.8% of the controls (P = 0.06), while no difference was seen for heterozygosity (33.0% versus 34.4%). Homozygotes had an increased risk of acquiring serious infections compared with patients who were heterozygous or homozygous for the normal allele (odds ratio 8.6, 95% confidence interval 1.5-47.6, P = 0.01). The time interval from the diagnosis of SLE to the first infectious event was shorter (P = 0.017), and the annual number of infectious events was 4 times higher, among homozygotes (P = 0.00002). They were especially prone to acquire pneumonia (P = 0.00004). CONCLUSION; Homozygosity for MBL variant alleles may explain much of the increased risk of complicating infections seen in SLE patients. Additionally, it is a minor risk factor for acquiring SLE.
OBJECTIVE: To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections. METHODS:MBL alleles and serum concentrations were determined by polymerase chain reaction and enzyme-linked immunosorbent assay, respectively, in 91 Danish patients with SLE and in 250 controls. RESULTS: Homozygosity for MBL variant alleles was observed in 7.7% of the SLEpatients compared with 2.8% of the controls (P = 0.06), while no difference was seen for heterozygosity (33.0% versus 34.4%). Homozygotes had an increased risk of acquiring serious infections compared with patients who were heterozygous or homozygous for the normal allele (odds ratio 8.6, 95% confidence interval 1.5-47.6, P = 0.01). The time interval from the diagnosis of SLE to the first infectious event was shorter (P = 0.017), and the annual number of infectious events was 4 times higher, among homozygotes (P = 0.00002). They were especially prone to acquire pneumonia (P = 0.00004). CONCLUSION; Homozygosity for MBL variant alleles may explain much of the increased risk of complicating infections seen in SLEpatients. Additionally, it is a minor risk factor for acquiring SLE.
Authors: Alex Smithson; Ana Muñoz; Belen Suarez; Sara Maria Soto; Rafael Perello; Alex Soriano; Jose Antonio Martinez; Jordi Vila; Juan Pablo Horcajada; Jose Mensa; Francisco Lozano Journal: Clin Vaccine Immunol Date: 2007-01-03
Authors: S Saevarsdottir; H Kristjansdottir; G Grondal; T Vikingsdottir; K Steinsson; H Valdimarsson Journal: Ann Rheum Dis Date: 2006-01-26 Impact factor: 19.103
Authors: M Perez-Castellano; M Peñaranda; A Payeras; J Milà; M Riera; J Vidal; F Pujalte; A Pareja; C Villalonga; N Matamoros Journal: Clin Exp Immunol Date: 2006-08 Impact factor: 4.330
Authors: Peter Garred; Morten A Nielsen; Jørgen A L Kurtzhals; Rajneesh Malhotra; Hans O Madsen; Bamenla Q Goka; Bartholomew D Akanmori; Robert B Sim; Lars Hviid Journal: Infect Immun Date: 2003-09 Impact factor: 3.441
Authors: Kenneth J Mukamal; Jennifer K Pai; Ellen S O'Meara; Russell P Tracy; Bruce M Psaty; Lewis H Kuller; Anne B Newman; Sachin Yende; Gary C Curhan; David S Siscovick; Eric B Rimm Journal: Respirology Date: 2009-11-23 Impact factor: 6.424
Authors: R Takahashi; A Tsutsumi; K Ohtani; D Goto; I Matsumoto; S Ito; N Wakamiya; T Sumida Journal: Clin Exp Immunol Date: 2004-06 Impact factor: 4.330