Literature DB >> 10524249

The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.

J Berger1, H Kurahashi, Y Takihara, K Shimada, H W Brock, F Randazzo.   

Abstract

Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two 1(3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34.

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Year:  1999        PMID： 10524249     DOI： 10.1016/s0378-1119(99)00285-1

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  9 in total

1.  Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance.

Authors:  Martha Stapels; Chelsea Piper; Tao Yang; Minghua Li; Cheri Stowell; Zhi-gang Xiong; Julie Saugstad; Roger P Simon; Scott Geromanos; James Langridge; Jing-quan Lan; An Zhou
Journal:  Sci Signal       Date:  2010-03-02       Impact factor: 8.192

2.  Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.

Authors:  Jinzhong Qin; Denille Van Buren; Hsien-Sung Huang; Lei Zhong; Raul Mostoslavsky; Schahram Akbarian; Hanno Hock
Journal:  J Biol Chem       Date:  2010-06-30       Impact factor: 5.157

3.  Sex comb on midleg like-2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors.

Authors:  Jiao-Jiao Yang; Hua Huang; Ming-Bing Xiao; Feng Jiang; Wen-Kai Ni; Yi-Fei Ji; Cui-Hua Lu; Run-Zhou Ni
Journal:  Exp Ther Med       Date:  2017-06-26       Impact factor: 2.447

4.  Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.

Authors:  Hiroaki Honda; Keiyo Takubo; Hideaki Oda; Kenjiro Kosaki; Tatsuya Tazaki; Norimasa Yamasaki; Kazuko Miyazaki; Kateri A Moore; Zen-ichiro Honda; Toshio Suda; Ihor R Lemischka
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-20       Impact factor: 11.205

5.  The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

Authors:  Stuart S Levine; Alona Weiss; Hediye Erdjument-Bromage; Zhaohui Shao; Paul Tempst; Robert E Kingston
Journal:  Mol Cell Biol       Date:  2002-09       Impact factor: 4.272

6.  Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.

Authors:  Juan Li; Anthony J Bench; George S Vassiliou; Nasios Fourouclas; Anne C Ferguson-Smith; Anthony R Green
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-30       Impact factor: 11.205

7.  Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

Authors:  Emilio Lecona; Luis Alejandro Rojas; Roberto Bonasio; Andrew Johnston; Oscar Fernández-Capetillo; Danny Reinberg
Journal:  PLoS Biol       Date:  2013-12-17       Impact factor: 8.029

Review 8.  MBT domain proteins in development and disease.

Authors:  Roberto Bonasio; Emilio Lecona; Danny Reinberg
Journal:  Semin Cell Dev Biol       Date:  2009-09-22       Impact factor: 7.727

9.  Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.

Authors:  Hai-hui Wu; Bing Su
Journal:  BMC Evol Biol       Date:  2008-07-05       Impact factor: 3.260
  9 in total

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