Literature DB >> 10523049

Some behavioural effects of risperidone in rats: comparison with haloperidol.

E Nowakowska1, A Chodera, K Kus, J Rybakowski.   

Abstract

Risperidone is a dopaminergic as well as a 5-HT2 antagonist. The drug was found to exert beneficial effects on both positive and negative symptoms of schizophrenia. Since recently, schizophrenia is regarded as a composite of not only positive and negative but also affective and cognitive symptoms, in this study the effects of risperidone compared with typical neuroleptic haloperidol, on affective and cognitive functions were investigated in rats (anxiolytic, antidepressive and memory tests). We found, that in contrast to haloperidol, risperidone had antidepressive, anxiolytic and memory enhancing effects. The results obtained correspond with favourable effects of risperidone on mood disturbances and cognitive functions of schizophrenic patients observed under clinical conditions.

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Year:  1999        PMID： 10523049     DOI： 10.1016/s0924-977x(99)00021-8

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  6 in total

1.  Propranolol blocks chronic risperidone treatment-induced enhancement of spatial working memory performance of rats in a delayed matching-to-place water maze task.

Authors:  Ee Peng Lim; Vivek Verma; Rajini Nagarajah; Gavin S Dawe
Journal:  Psychopharmacology (Berl)       Date:  2007-01-16       Impact factor: 4.530

2.  Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in rats.

Authors:  A V Terry; S E Warner; L Vandenhuerk; A Pillai; S P Mahadik; G Zhang; M G Bartlett
Journal:  Neuroscience       Date:  2008-08-27       Impact factor: 3.590

3.  Comparison of the effects of antipsychotics on a delayed radial maze task in the rat.

Authors:  Mary C Wolff; J David Leander
Journal:  Psychopharmacology (Berl)       Date:  2003-04-23       Impact factor: 4.530

4.  Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance.

Authors:  A V Terry; D A Gearhart; S E Warner; G Zhang; M G Bartlett; M-L Middlemore; W D Beck; S P Mahadik; J L Waller
Journal:  Neuroscience       Date:  2007-04-16       Impact factor: 3.590

5.  Protracted effects of chronic oral haloperidol and risperidone on nerve growth factor, cholinergic neurons, and spatial reference learning in rats.

Authors:  A V Terry; D A Gearhart; S Warner; E J Hohnadel; M-L Middlemore; G Zhang; M G Bartlett; S P Mahadik
Journal:  Neuroscience       Date:  2007-09-14       Impact factor: 3.590

6.  Waterborne Risperidone Decreases Stress Response in Zebrafish.

Authors:  Renan Idalencio; Fabiana Kalichak; João Gabriel Santos Rosa; Tiago Acosta de Oliveira; Gessi Koakoski; Darlan Gusso; Murilo Sander de Abreu; Ana Cristina Varrone Giacomini; Heloísa Helena de Alcântara Barcellos; Angelo L Piato; Leonardo José Gil Barcellos
Journal:  PLoS One       Date:  2015-10-16       Impact factor: 3.240
  6 in total

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