Literature DB >> 10522708

Antagonism of the TXA2 receptor by seratrodast: a structural approach.

J Wouters1, F Durant, B Masereel.   

Abstract

The crystal structure of seratrodast (AA-2414), a potent thromboxane A2 (TXA2) receptor antagonist, served as starting point to docking studies with the modeled human TXA2 receptor. This structural approach provides rational basis for the design of new antagonists within the aryl sulfonamide family.

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Year:  1999        PMID： 10522708     DOI： 10.1016/s0960-894x(99)00490-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Neryl butyrate induces contractile effects on isolated preparations of rat aorta.

Authors:  Emanuella Feitosa de Carvalho; Kalinne Kelly Lima Gadelha; Daniel Maia Nogueira de Oliveira; Karine Lima-Silva; Francisco José Batista-Lima; Teresinha Silva de Brito; Suliana Mesquita Paula; Moisés Tolentino Bento da Silva; Armênio Aguiar Dos Santos; Pedro Jorge Caldas Magalhães
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-08-16       Impact factor: 3.000

2.  Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway.

Authors:  He Zhang; Yuyao Zhang; Xiaolei Tang; Wenjie Su; Chunhui Yang; Daian Pan; Daqing Zhao; Bin Qi; Xiangyan Li
Journal:  Biomed Res Int       Date:  2022-09-20       Impact factor: 3.246
  2 in total

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