Literature DB >> 10522707

2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.

P Ertl1, D Cooper, G Allen, M J Slater.   

Abstract

A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay.

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Year:  1999        PMID： 10522707     DOI： 10.1016/s0960-894x(99)00489-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Cytotoxic effects of N-(3-chloro-1,4-dioxo 1,4-dihydro-naphthalen-2-yl)-benzamide on androgen-dependent and -independent prostate cancer cell lines.

Authors:  Yasmine M Kanaan; Douglas F White; Jharna R Das; Solomon Berhe; Oladapo Bakare; Hillaire Kenguele; Desta Beyene; Yanfei Zhou; Agnes A Day; Robert L Copeland
Journal:  Anticancer Res       Date:  2010-02       Impact factor: 2.480

2.  Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication.

Authors:  Emmerson C B da Costa; Raquel Amorim; Fernando C da Silva; David R Rocha; Michelle P Papa; Luciana B de Arruda; Ronaldo Mohana-Borges; Vitor F Ferreira; Amilcar Tanuri; Luciana J da Costa; Sabrina B Ferreira
Journal:  PLoS One       Date:  2013-12-20       Impact factor: 3.240
  2 in total

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