| Literature DB >> 10522697 |
J L Wright1, T F Gregory, P A Boxer, L T Meltzer, K A Serpa, L D Wise.
Abstract
4-Benzyl-1-[4-(1H-imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent antagonist of the NR1A/2B subtype of the NMDA receptor. When dosed orally, this compound potentiates the effects of L-DOPA in the 6-hydroxydopamine-lesioned rat, a model of Parkinson's disease.Entities:
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Year: 1999 PMID： 10522697 DOI： 10.1016/s0960-894x(99)00482-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823