Literature DB >> 10521712

Troponin: structure, properties, and mechanism of functioning.

V L Filatov1, A G Katrukha, T V Bulargina, N B Gusev.   

Abstract

This review discusses the structure and properties of the isolated components of troponin, their interaction, and the mechanisms of regulation of contractile activity of skeletal and cardiac muscle. Data on the structure of troponin C in crystals and in solution are presented. The Ca2+-induced conformational changes of troponin C structure are described. The structure of troponin I is analyzed and its interaction with other components of actin filaments is discussed. Data on phosphorylation of troponin I by various protein kinases are presented. The role of troponin I phosphorylation in the regulation of contractile activity of the heart is analyzed. The structural properties of troponin T and its interaction with other components of thin filaments are described. Data on the phosphorylation of troponin T are presented and the effect of troponin T phosphorylation on contractile activity of different muscles is discussed. Modern models of the functioning of troponin are presented and analyzed.

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Year:  1999        PMID： 10521712

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  44 in total

1.  Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.

Authors:  Nicholas Swindle; Svetlana B Tikunova
Journal:  Biochemistry       Date:  2010-06-15       Impact factor: 3.162

2.  Distinct troponin C isoform requirements in cardiac and skeletal muscle.

Authors:  Vanessa M Sogah; Fabrizio C Serluca; Mark C Fishman; Deborah L Yelon; Calum A Macrae; John D Mably
Journal:  Dev Dyn       Date:  2010-11       Impact factor: 3.780

3.  Rapid and Sensitive Detection of Troponin I-T-C Complex from Human Serum using Microwave-Accelerated Metal-Enhanced Fluorescence.

Authors:  Kadir Aslan
Journal:  Nano Biomed Eng       Date:  2011

4.  Differential expression of mutually exclusive exons of the fast skeletal muscle troponin T gene in the chicken wing and leg muscles.

Authors:  Miho Jozaki; Kouji Hosoda; Jun-Ichi Miyazaki
Journal:  J Muscle Res Cell Motil       Date:  2002       Impact factor: 2.698

5.  Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL.

Authors:  Anselm Geiger; Luigi Russo; Thomas Gensch; Thomas Thestrup; Stefan Becker; Karl-Peter Hopfner; Christian Griesinger; Gregor Witte; Oliver Griesbeck
Journal:  Biophys J       Date:  2012-05-15       Impact factor: 4.033

6.  Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex.

Authors:  William Schlecht; King-Lun Li; Dehong Hu; Wenji Dong
Journal:  Chem Biol Drug Des       Date:  2015-09-16       Impact factor: 2.817

7.  The structural role of high molecular weight tropomyosins in dipteran indirect flight muscle and the effect of phosphorylation.

Authors:  Jesús Mateos; Raúl Herranz; Alberto Domingo; John Sparrow; Roberto Marco
Journal:  J Muscle Res Cell Motil       Date:  2006-06-04       Impact factor: 2.698

8.  Integration of male mating and feeding behaviors in Caenorhabditis elegans.

Authors:  Todd R Gruninger; Daisy G Gualberto; Brigitte LeBoeuf; L Rene Garcia
Journal:  J Neurosci       Date:  2006-01-04       Impact factor: 6.167

9.  Diversification and independent evolution of troponin C genes in insects.

Authors:  Raul Herranz; Jesus Mateos; Roberto Marco
Journal:  J Mol Evol       Date:  2005-01       Impact factor: 2.395

10.  Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms.

Authors:  Jingui Zhu; Yongqiao Sun; Fa-Qing Zhao; Jun Yu; Roger Craig; Songnian Hu
Journal:  BMC Genomics       Date:  2009-03-19       Impact factor: 3.969
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