| Literature DB >> 10520643 |
A Geusau, E Tschachler, M Meixner, S Sandermann, O Päpke, C Wolf, E Valic, G Stingl, M McLachlan.
Abstract
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10520643 DOI： 10.1016/S0140-6736(99)04271-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321