Literature DB >> 10520641

Association of CCR5 delta32 with reduced risk of asthma.

I P Hall, A Wheatley, G Christie, C McDougall, R Hubbard, P J Helms.   

Abstract

We report that individuals carrying the CCR5 delta32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.

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Year:  1999        PMID： 10520641     DOI： 10.1016/s0140-6736(99)03425-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  15 in total

1.  A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5.

Authors:  T Dragic; A Trkola; D A Thompson; E G Cormier; F A Kajumo; E Maxwell; S W Lin; W Ying; S O Smith; T P Sakmar; J P Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  Association of CCR5Delta32 with reduced risk of childhood but not adult asthma.

Authors:  P Srivastava; P J Helms; D Stewart; M Main; G Russell
Journal:  Thorax       Date:  2003-03       Impact factor: 9.139

3.  Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5.

Authors:  T Shioda; E E Nakayama; Y Tanaka; X Xin; H Liu; A Kawana-Tachikawa; A Kato; Y Sakai; Y Nagai; A Iwamoto
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

Review 4.  G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective.

Authors:  Miles D Thompson; Jun Takasaki; Valérie Capra; G Enrico Rovati; Kathy A Siminovitch; W McIntyre Burnham; Thomas J Hudson; Yohan Bossé; David E C Cole
Journal:  Mol Diagn Ther       Date:  2006       Impact factor: 4.074

Review 5.  Is the CCR5 Δ 32 mutation associated with immune system-related diseases?

Authors:  Khodayar Ghorban; Maryam Dadmanesh; Gholamhossein Hassanshahi; Mohammad Momeni; Mohammad Zare-Bidaki; Mohammad Kazemi Arababadi; Derek Kennedy
Journal:  Inflammation       Date:  2013-06       Impact factor: 4.092

Review 6.  Interactions between genes and environmental factors in asthma and atopy: new developments.

Authors:  Claudia Sengler; Susanne Lau; Ulrich Wahn; Renate Nickel
Journal:  Respir Res       Date:  2001-10-31

Review 7.  Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma.

Authors:  L J Palmer; W O Cookson
Journal:  Respir Res       Date:  2001-03-08

8.  CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study.

Authors:  Erinaldo Ubirajara Damasceno dos Santos; Géssica Dayane Cordeiro de Lima; Micheline de Lucena Oliveira; Sandra de Andrade Heráclio; Hildson Dornelas Angelo da Silva; Sergio Crovella; Maria de Mascena Diniz Maia; Paulo Roberto Eleutério de Souza
Journal:  Mem Inst Oswaldo Cruz       Date:  2016-03-15       Impact factor: 2.743

9.  Upregulation of expression of the chemokine receptor CCR5 by hydrogen peroxide in human monocytes.

Authors:  Geneviève Lehoux; Christian Le Gouill; Jana Stankova; Marek Rola-Pleszczynski
Journal:  Mediators Inflamm       Date:  2003-02       Impact factor: 4.711

Review 10.  Association studies for asthma and atopic diseases: a comprehensive review of the literature.

Authors:  Sabine Hoffjan; Dan Nicolae; Carole Ober
Journal:  Respir Res       Date:  2003-12-04
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