E F Lyamuya1, M I Matee, M Kasubi, F Scheutz. 1. Department of Microbiology and Immunology, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.
Abstract
OBJECTIVE: To determine immunoglobulin levels in HIV-1 seronegative and HIV-1 seropositive children at different clinical stages of HIV infection. DESIGN: Cross-sectional study. SETTING: Lugalo and Mwanayamala mother and child clinics in Dar es Salaam. SUBJECTS: Two hundred and ninety-nine children aged 18 months to five years. MAIN OUTCOME MEASURES: Estimation of immunoglobulin classes (IgG, IgA, IgM, IgD and IgE). RESULTS: Mean serum levels of all immunoglobulin classes were significantly higher (p < 0.0001) among the HIV-1 seropositive children (IgG = 22.9 g/l, IgA = 2.2 g/l, IgM 2.7 g/l, IgD 101.5 IU/ml and IgE 887.7 IU/ml) than among the HIV-1 seronegative children (IgG = 11.3 g/l, IgA = 1.0 g/l, IgM = 1.5 g/l, IgD = 27.8 UI/ml and IgE 341.3 UI/ml). The percentages of HIV-infected children with immunoglobulin concentrations above mean level were 83% for IgG, 77% for IgA, 78% for IgM, 73% for IgD and 78% for IgE. CONCLUSION: HIV seropositive children have higher levels of immunoglobulin than seronegative children. There was no correlation between the levels of immunoglobulin classes and CDC clinical staging.
OBJECTIVE: To determine immunoglobulin levels in HIV-1 seronegative and HIV-1 seropositive children at different clinical stages of HIV infection. DESIGN: Cross-sectional study. SETTING: Lugalo and Mwanayamala mother and child clinics in Dar es Salaam. SUBJECTS: Two hundred and ninety-nine children aged 18 months to five years. MAIN OUTCOME MEASURES: Estimation of immunoglobulin classes (IgG, IgA, IgM, IgD and IgE). RESULTS: Mean serum levels of all immunoglobulin classes were significantly higher (p < 0.0001) among the HIV-1 seropositive children (IgG = 22.9 g/l, IgA = 2.2 g/l, IgM 2.7 g/l, IgD 101.5 IU/ml and IgE 887.7 IU/ml) than among the HIV-1 seronegative children (IgG = 11.3 g/l, IgA = 1.0 g/l, IgM = 1.5 g/l, IgD = 27.8 UI/ml and IgE 341.3 UI/ml). The percentages of HIV-infectedchildren with immunoglobulin concentrations above mean level were 83% for IgG, 77% for IgA, 78% for IgM, 73% for IgD and 78% for IgE. CONCLUSION: HIV seropositive children have higher levels of immunoglobulin than seronegative children. There was no correlation between the levels of immunoglobulin classes and CDC clinical staging.
Entities:
Keywords:
Africa; Africa South Of The Sahara; Age Factors; Antibodies--analysis; Biology; Child; Cross Sectional Analysis; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Examinations And Diagnoses; Hiv Infections; Immunity; Immunologic Factors; Laboratory Examinations And Diagnoses; Physiology; Population; Population Characteristics; Research Methodology; Research Report; Tanzania; Viral Diseases; Youth