S A Ahmed1, M H Shalayel. 1. Department of Biochemistry, Faculty of Medicine, University of Khartoum.
Abstract
OBJECTIVE: To study the state of insulin resistance which occurs in pregnancy and the possible role of cortisol in augmentation of this state. DESIGN: Case-control study. SETTING: Khartoum teaching hospital, Khartoum north hospital, Soba hospital, Ibrahim Malek hospital, maternity hospital and Fath-Elbasheer referral centre from January to August 1996. SUBJECTS: Thirty pregnant women with gestational diabetes mellitus(GDM) and thirty pregnant women with impaired glucose tolerance(IGT) were compared with thirty control pregnant women with normal glucose tolerance. RESULTS: The GDM and the IGT groups were found to have significantly higher levels of serum cortisol than that of the control group [937.2 +/- 79.4 nmol/l (mean +/- S.E.) and 794.2 +/- 60.5 vs 597.3 +/- 30.9 respectively, p < 0.0006]. CONCLUSION: Cortisol has a great role to play in the deterioration of glucose tolerance in pregnancy.
OBJECTIVE: To study the state of insulin resistance which occurs in pregnancy and the possible role of cortisol in augmentation of this state. DESIGN: Case-control study. SETTING: Khartoum teaching hospital, Khartoum north hospital, Soba hospital, Ibrahim Malek hospital, maternity hospital and Fath-Elbasheer referral centre from January to August 1996. SUBJECTS: Thirty pregnant women with gestational diabetes mellitus(GDM) and thirty pregnant women with impaired glucose tolerance(IGT) were compared with thirty control pregnant women with normal glucose tolerance. RESULTS: The GDM and the IGT groups were found to have significantly higher levels of serum cortisol than that of the control group [937.2 +/- 79.4 nmol/l (mean +/- S.E.) and 794.2 +/- 60.5 vs 597.3 +/- 30.9 respectively, p < 0.0006]. CONCLUSION:Cortisol has a great role to play in the deterioration of glucose tolerance in pregnancy.
Entities:
Keywords:
Adrenal Cortex Hormones; Africa; Arab Countries; Biology; Case Control Studies; Clinical Research; Demographic Factors; Developing Countries; Diabetes Mellitus--women; Diseases; Endocrine System; Examinations And Diagnoses; Glucose Tolerance Test; Hormones; Laboratory Examinations And Diagnoses; Laboratory Procedures; Northern Africa; Physiology; Population; Population Characteristics; Pregnant Women; Research Methodology; Research Report; Studies; Sudan; Women