| Literature DB >> 10520009 |
L Pagano1, A Pulsoni, M E Tosti, L Annino, A Mele, A Camera, B Martino, C Guglielmi, R Cerri, E Di Bona, R Invernizzi, C Castagnola, R Bassan, L Mele, G Todeschini, G Leone, F Mandelli.
Abstract
Between July 1992 and June 1996, 901 new cases of adult acute lymphoblastic leukaemia were recorded in the GIMEMA Archive of Adult Acute Leukaemia; 21 of them (2.3%) had a previous primary malignancy (PM). We found that secondary acute lymphoblastic leukaemia cases (sALL) presented with older age, a high incidence of pre-pre-B immunophenotype and a significantly higher prevalence of cancer among relatives compared to de novo ALL. The leukaemogenic activity of the cytotoxic drugs employed for the treatment of PM may have played a potential role in only a proportion of patients, opening the possibility that some sALL patients may have developed two or more malignancies due to individual predisposing factors.Entities:
Mesh：
Year: 1999 PMID： 10520009 DOI： 10.1046/j.1365-2141.1999.01636.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998