| Literature DB >> 10519645 |
K Kemparaju1, T P Krishnakanth, T Veerabasappa Gowda.
Abstract
An acidic phospholipase A2 (EC-I-PLA2) has been purified from the Indian saw-scaled viper (Echis carinatus) venom through a combination of column chromatography and electrophoresis. EC-I-PLA2 has a molecular weight of 16000 by SDS-PAGE. It was focussed between pH 4.2 and 4.8 by isoelectro focussing. EC-I-PLA2 was non-lethal to mice and devoid of neurotoxicity, myotoxicity, anticoagulant activity and cytotoxicity. It induced mild oedema in the foot pads of mice. The purified PLA2 inhibited ADP, collagen and epinephrine induced human platelet aggregation and the inhibition was both dose and time dependent.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10519645 DOI： 10.1016/s0041-0101(99)00104-x
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033