Literature DB >> 10519158

Oxygen-independent microbicidal mechanisms of phagocytes.

T Ganz1.   

Abstract

The principal biological function of phagocytic cells is the destruction of invading microorganisms. Following phagocytosis, microbes are exposed to multiple antimicrobial substances ranging in complexity from simple oxygen radicals to large proteins. These substances disrupt various microbial structures and eventually kill and digest most of the invaders. This review is focused on oxygen-independent microbicidal mechanisms in granulocytes and macrophages.

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Year:  1999        PMID： 10519158     DOI： 10.1111/paa.1999.111.5.390

Source DB:  PubMed          Journal:  Proc Assoc Am Physicians        ISSN： 1081-650X


  6 in total

1.  Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.

Authors:  Timofey Kalupov; Michèle Brillard-Bourdet; Sébastien Dadé; Hélène Serrano; Julien Wartelle; Nicolas Guyot; Luiz Juliano; Thierry Moreau; Azzaq Belaaouaj; Francis Gauthier
Journal:  J Biol Chem       Date:  2009-10-15       Impact factor: 5.157

2.  Macrophage elastase kills bacteria within murine macrophages.

Authors:  A McGarry Houghton; William O Hartzell; Clinton S Robbins; F Xavier Gomis-Rüth; Steven D Shapiro
Journal:  Nature       Date:  2009-06-17       Impact factor: 49.962

3.  Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia.

Authors:  Rym Benabid; Julien Wartelle; Laurette Malleret; Nicolas Guyot; Sophie Gangloff; François Lebargy; Azzaq Belaaouaj
Journal:  J Biol Chem       Date:  2012-08-27       Impact factor: 5.157

4.  Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection.

Authors:  Mahmoud M Bahgat; Paulina Błazejewska; Klaus Schughart
Journal:  Virol J       Date:  2011-01-20       Impact factor: 4.099

5.  Neutrophil elastase stimulates MUC5AC expression in human biliary epithelial cells: a possible pathway of PKC/Nox/ROS.

Authors:  Yu Tian; Min Li; Shuodong Wu; Duoliang Wang; Ben Sun; Junqing Xie; Hong Wang
Journal:  Arch Med Sci       Date:  2017-04-20       Impact factor: 3.318

6.  Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium.

Authors:  Rachel Boxio; Julien Wartelle; Béatrice Nawrocki-Raby; Brice Lagrange; Laurette Malleret; Timothee Hirche; Clifford Taggart; Yves Pacheco; Gilles Devouassoux; Abderrazzaq Bentaher
Journal:  Respir Res       Date:  2016-10-17
  6 in total

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