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Literature DB >> 10518591

RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.

Y Wang¹, D C Newton, G B Robb, C L Kau, T L Miller, A H Cheung, A V Hall, S VanDamme, J N Wilcox, P A Marsden.

Abstract

A comprehensive analysis of the structure of neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be the most structurally diverse human gene described to date in terms of promoter usage. Nine unique exon 1 variants are variously used for transcript initiation in diverse tissues, and each is expressed from a unique 5'-flanking region. The dependence on unique genomic regions to control transcription initiation in a cell-specific fashion burdens the transcripts with complex 5'-mRNA leader sequences. Elaborate splicing patterns that involve alternatively spliced leader exons and exon skipping have been superimposed on this diversity. Highly structured nNOS mRNA 5'-untranslated regions, which have profound effects on translation both in vitro and in cells, contain cis RNA elements that modulate translational efficiency in response to changes in cellular phenotype.

Entities: Gene Species

Mesh：

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Year: 1999 PMID： 10518591 PMCID： PMC18427 DOI： 10.1073/pnas.96.21.12150

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

Review 1. Neuronal NOS: gene structure, mRNA diversity, and functional relevance.

Authors: Y Wang; D C Newton; P A Marsden
Journal: Crit Rev Neurobiol Date: 1999

2. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia.

Authors: I Stein; A Itin; P Einat; R Skaliter; Z Grossman; E Keshet
Journal: Mol Cell Biol Date: 1998-06 Impact factor: 4.272

Review 3. Splicing regulation in neurons: tinkering with cell-specific control.

Authors: P J Grabowski
Journal: Cell Date: 1998-03-20 Impact factor: 41.582

4. Functional association between promoter structure and transcript alternative splicing.

Authors: P Cramer; C G Pesce; F E Baralle; A R Kornblihtt
Journal: Proc Natl Acad Sci U S A Date: 1997-10-14 Impact factor: 11.205

5. Developmentally regulated use of alternative promoters creates a novel platelet-derived growth factor receptor transcript in mouse teratocarcinoma and embryonic stem cells.

Authors: T H Vu; G R Martin; P Lee; D Mark; A Wang; L T Williams
Journal: Mol Cell Biol Date: 1989-10 Impact factor: 4.272

Review 6. A survey on intron and exon lengths.

Authors: J D Hawkins
Journal: Nucleic Acids Res Date: 1988-11-11 Impact factor: 16.971

7. Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.

Authors: M A Lee; L Cai; N Hübner; Y A Lee; K Lindpaintner
Journal: J Clin Invest Date: 1997-09-15 Impact factor: 14.808

8. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels.

Authors: J N Wilcox; R R Subramanian; C L Sundell; W R Tracey; J S Pollock; D G Harrison; P A Marsden
Journal: Arterioscler Thromb Vasc Biol Date: 1997-11 Impact factor: 8.311

9. Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.

Authors: D L Bentley; M Groudine
Journal: Mol Cell Biol Date: 1986-10 Impact factor: 4.272

10. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

Authors: C Y Chen; F Del Gatto-Konczak; Z Wu; M Karin
Journal: Science Date: 1998-06-19 Impact factor: 47.728

43 in total

1. Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism.

Authors: M Sasaki; M Gonzalez-Zulueta; H Huang; W J Herring; S Ahn; D D Ginty; V L Dawson; T M Dawson
Journal: Proc Natl Acad Sci U S A Date: 2000-07-18 Impact factor: 11.205

2. Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain.

Authors: N Peunova; V Scheinker; H Cline; G Enikolopov
Journal: J Neurosci Date: 2001-11-15 Impact factor: 6.167

3. The 5' RNA terminus of spleen necrosis virus stimulates translation of nonviral mRNA.

Authors: T M Roberts; K Boris-Lawrie
Journal: J Virol Date: 2000-09 Impact factor: 5.103

Review 4. Research progress on neurobiology of neuronal nitric oxide synthase.

Authors: Chun-Xia Luo; Dong-Ya Zhu
Journal: Neurosci Bull Date: 2011-02 Impact factor: 5.203

5. Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains.

Authors: Roland P Kuiper; Marga Schepens; José Thijssen; Eric F P M Schoenmakers; Ad Geurts van Kessel
Journal: Nucleic Acids Res Date: 2004-04-26 Impact factor: 16.971