| Literature DB >> 10517968 |
T Kubota1, K Hirota, N Anzawa, H Yoshida, T Kushikata, A Matsuki.
Abstract
Physostigmine is known to antagonize ketamine anesthesia. In this study, effects of physostigmine (0.1 mg kg(-1) i.p.) on ketamine (100 mg kg(-1) i.p.)-induced anesthesia time and noradrenaline release from the medial prefrontal cortex in rats were examined. Ketamine produced anesthesia for 27+/-1 min and increased noradrenaline release to 405% of the basal. Physostigmine significantly reduced anesthesia time to 23+/-1 min (p<0.05), and noradrenaline to 248% (p<0.05). Therefore, noradrenaline release may play an important role in ketamine anesthesia.Entities:
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Year: 1999 PMID： 10517968 DOI： 10.1016/s0006-8993(99)01793-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252