Literature DB >> 10514905

Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives.

C Ochoa1, E Pérez, R Pérez, M Suárez, E Ochoa, H Rodríguez, A Gómez Barrio, S Muelas, J J Nogal, R A Martínez.   

Abstract

In a search for antiprotozoan compounds, 34 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan activity. In vivo assays of compounds which showed remarkable in vitro activity against T. vaginalis were carried out.

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Year:  1999        PMID： 10514905     DOI： 10.1055/s-0031-1300499

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  6 in total

1.  In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi.

Authors:  Juliana Saraiva; Celeste Vega; Mirian Rolon; Rosangela da Silva; Márcio Luis Andrade E Silva; Paulo Marcos Donate; Jairo Kenupp Bastos; Alícia Gomez-Barrio; Sérgio de Albuquerque
Journal:  Parasitol Res       Date:  2006-10-12       Impact factor: 2.289

2.  In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.

Authors:  Adriana M C Canavaci; Juan M Bustamante; Angel M Padilla; Cecilia M Perez Brandan; Laura J Simpson; Dan Xu; Courtney L Boehlke; Rick L Tarleton
Journal:  PLoS Negl Trop Dis       Date:  2010-07-13

3.  Bond-based linear indices in QSAR: computational discovery of novel anti-trichomonal compounds.

Authors:  Yovani Marrero-Ponce; Alfredo Meneses-Marcel; Oscar M Rivera-Borroto; Ramón García-Domenech; Jesus Vicente De Julián-Ortiz; Alina Montero; José Antonio Escario; Alicia Gómez Barrio; David Montero Pereira; Juan José Nogal; Ricardo Grau; Francisco Torrens; Christian Vogel; Vicente J Arán
Journal:  J Comput Aided Mol Des       Date:  2008-05-16       Impact factor: 3.686

4.  Thiadiazine derivatives as antiprotozoal new drugs.

Authors:  Julieta Coro Bermello; Rolando Pérez Piñeiro; Lianet Monzote Fidalgo; Hortensia Rodríguez Cabrera; Margarita Suárez Navarro
Journal:  Open Med Chem J       Date:  2011-03-09

Review 5.  Thiadiazines, N,N-heterocycles of biological relevance.

Authors:  Hortensia Rodríguez; Margarita Suárez; Fernando Albericio
Journal:  Molecules       Date:  2012-06-25       Impact factor: 4.411

Review 6.  The Versatility in the Applications of Dithiocarbamates.

Authors:  Timothy O Ajiboye; Titilope T Ajiboye; Riadh Marzouki; Damian C Onwudiwe
Journal:  Int J Mol Sci       Date:  2022-01-24       Impact factor: 5.923
  6 in total

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