Literature DB >> 10514316

Strong antinociceptive effect of incarvillateine, a novel monoterpene alkaloid from Incarvillea sinensis.

M Nakamura1, Y M Chi, W M Yan, Y Nakasugi, T Yoshizawa, N Irino, F Hashimoto, J Kinjo, T Nohara, S Sakurada.   

Abstract

Incarvillea sinensis is a wild plant distributed in northern China. The dried whole plant has been traditionally used to treat rheumatism and relieve pain as an ancient Chinese crude drug. To investigate its antinociceptive activity, we evaluated several fractions derived from the methanolic extract of Incarvillea sinensis in the formalin-induced pain model in mice. Incarvillateine, a novel monoterpene alkaloid, has been found to show significant antinociceptive activity. Here we report the antinociceptive activity of incarvillateine and compare its activity with that of morphine. Additionally, we suggest that its action may be related to influence on the central opioid pathways.

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Year:  1999        PMID： 10514316     DOI： 10.1021/np990041c

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

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10.  Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system.

Authors:  Mei-Liang Wang; Gang Yu; Shou-Pu Yi; Feng-Ying Zhang; Zhi-Tong Wang; Bin Huang; Rui-Bin Su; Yan-Xing Jia; Ze-Hui Gong
Journal:  Sci Rep       Date:  2015-11-03       Impact factor: 4.379
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