| Literature DB >> 10514299 |
Y J Lim1, J S Kim, K S Im, J H Jung, C O Lee, J Hong, D k Kim.
Abstract
New polyacetylenic alcohols with a C(45) carbon skeleton (2) and with an enone moiety in the alkyl chain (C(46), 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.Entities:
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Year: 1999 PMID： 10514299 DOI： 10.1021/np9900371
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050