Literature DB >> 10513560

Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation.

J Ichikawa1, H Y Meltzer.   

Abstract

The anticonvulsant mood stabilizers valproic acid (250, 500 but not 50 mg/kg) and carbamazepine (6, 12.5 but not 3 mg/kg) were found to increase extracellular dopamine levels in rat medial prefrontal cortex, but not nucleus accumbens. Increased prefrontal dopamine was completely abolished by the selective 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexa necarboxamide (WAY100635, 0.05 mg/kg). Anticonvulsants and clozapine may share a common mood stabilizing mechanism since clozapine is reported to have mood stabilizing effects and increase prefrontal dopamine by 5-HT1A receptor activation.

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Year:  1999        PMID： 10513560     DOI： 10.1016/s0014-2999(99)00517-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Clinical and imaging features of Othello's syndrome.

Authors:  J Graff-Radford; J L Whitwell; Y E Geda; K A Josephs
Journal:  Eur J Neurol       Date:  2011-04-25       Impact factor: 6.089

2.  Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.

Authors:  Yu Ohmura; Iku Tsutsui-Kimura; Haruko Kumamoto; Masabumi Minami; Takeshi Izumi; Taku Yamaguchi; Takayuki Yoshida; Mitsuhiro Yoshioka
Journal:  Psychopharmacology (Berl)       Date:  2011-09-21       Impact factor: 4.530

3.  Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats.

Authors:  Shagufta Ahmad; Leslie J Fowler; Peter S Whitton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-01-20       Impact factor: 3.000

4.  Pharmacological discrimination between effects of carbamazepine on hippocampal basal, Ca(2+)- and K(+)-evoked serotonin release.

Authors:  Y Kawata; M Okada; T Murakami; A Kamata; G Zhu; S Kaneko
Journal:  Br J Pharmacol       Date:  2001-06       Impact factor: 8.739

Review 5.  Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

Authors:  António F Ambrósio; Patrício Soares-Da-Silva; Caetana M Carvalho; Arsélio P Carvalho
Journal:  Neurochem Res       Date:  2002-02       Impact factor: 3.996

6.  Determination of effects of antiepileptic drugs on SNAREs-mediated hippocampal monoamine release using in vivo microdialysis.

Authors:  T Murakami; M Okada; Y Kawata; G Zhu; A Kamata; S Kaneko
Journal:  Br J Pharmacol       Date:  2001-10       Impact factor: 8.739

Review 7.  Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.

Authors:  Wolfgang Löscher
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

8.  Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects.

Authors:  Nicholas J Delva; Deborah L Brooks; Michael Franklin; Khalid al-Said; Emily R Hawken; Zul Merali; J Stuart Lawson; Arun V Ravindran
Journal:  J Psychiatry Neurosci       Date:  2002-11       Impact factor: 6.186

9.  Effects of mood stabilizers on marble-burying behavior in mice: involvement of GABAergic system.

Authors:  Nobuaki Egashira; Moe Abe; Atsunori Shirakawa; Tomiko Niki; Kenichi Mishima; Katsunori Iwasaki; Ryozo Oishi; Michihiro Fujiwara
Journal:  Psychopharmacology (Berl)       Date:  2012-10-21       Impact factor: 4.530

10.  Effect of acute and chronic lamotrigine on basal and stimulated extracellular 5-hydroxytryptamine and dopamine in the hippocampus of the freely moving rat.

Authors:  Shagufta Ahmad; Leslie J Fowler; Peter S Whitton
Journal:  Br J Pharmacol       Date:  2004-03-22       Impact factor: 8.739
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