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Literature DB >> 10512874

Association of the cell cycle transcription factor Mbp1 with the Skn7 response regulator in budding yeast.

N Bouquin¹, A L Johnson, B A Morgan, L H Johnston.

Abstract

We previously isolated the SKN7 gene in a screen designed to isolate new components of the G1-S cell cycle transcription machinery in budding yeast. We have now found that Skn7 associates with Mbp1, the DNA-binding component of the G1-S transcription factor DSC1/MBF. SKN7 and MBP1 show several genetic interactions. Skn7 overexpression is lethal and is suppressed by a mutation in MBP1. Similarly, high overexpression of Mbp1 is lethal and can be suppressed by skn7 mutations. SKN7 is also required for MBP1 function in a mutant compromised for G1-specific transcription. Gel-retardation assays indicate that Skn7 is not an integral part of MBF. However, a physical interaction between Skn7 and Mbp1 was detected using two-hybrid assays and GST pulldowns. Thus, Skn7 and Mbp1 seem to form a transcription factor independent of MBF. Genetic data suggest that this new transcription factor could be involved in the bud-emergence process.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10512874 PMCID： PMC25606 DOI： 10.1091/mbc.10.10.3389

Source DB: PubMed Journal: Mol Biol Cell ISSN： 1059-1524 Impact factor: 4.138

46 in total

1. Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Authors: B Baum; J Wuarin; P Nurse
Journal: EMBO J Date: 1997-08-01 Impact factor: 11.598

2. Cell cycle control by an essential bacterial two-component signal transduction protein.

Authors: K C Quon; G T Marczynski; L Shapiro
Journal: Cell Date: 1996-01-12 Impact factor: 41.582

3. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

Authors: A S Alberts; N Bouquin; L H Johnston; R Treisman
Journal: J Biol Chem Date: 1998-04-10 Impact factor: 5.157

4. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae.

Authors: B A Morgan; G R Banks; W M Toone; D Raitt; S Kuge; L H Johnston
Journal: EMBO J Date: 1997-03-03 Impact factor: 11.598

5. The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.

Authors: R F Siegmund; K A Nasmyth
Journal: Mol Cell Biol Date: 1996-06 Impact factor: 4.272

6. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.

Authors: S Li; A Ault; C L Malone; D Raitt; S Dean; L H Johnston; R J Deschenes; J S Fassler
Journal: EMBO J Date: 1998-12-01 Impact factor: 11.598

7. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.

Authors: P T Spellman; G Sherlock; M Q Zhang; V R Iyer; K Anders; M B Eisen; P O Brown; D Botstein; B Futcher
Journal: Mol Biol Cell Date: 1998-12 Impact factor: 4.138

8. A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.

Authors: C Koch; T Moll; M Neuberg; H Ahorn; K Nasmyth
Journal: Science Date: 1993-09-17 Impact factor: 47.728

9. A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

Authors: H Nonaka; K Tanaka; H Hirano; T Fujiwara; H Kohno; M Umikawa; A Mino; Y Takai
Journal: EMBO J Date: 1995-12-01 Impact factor: 11.598

6. Histidine kinase two-component response regulator proteins regulate reproductive development, virulence, and stress responses of the fungal cereal pathogens Cochliobolus heterostrophus and Gibberella zeae.

Authors: Shinichi Oide; Jinyuan Liu; Sung-Hwan Yun; Dongliang Wu; Alex Michev; May Yee Choi; Benjamin A Horwitz; B Gillian Turgeon
Journal: Eukaryot Cell Date: 2010-10-29

7. Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus.

Authors: Kosuke Izumitsu; Akira Yoshimi; Chihiro Tanaka
Journal: Eukaryot Cell Date: 2006-12-08

Association of the cell cycle transcription factor Mbp1 with the Skn7 response regulator in budding yeast.

1. Control of S-phase periodic transcription in the fission yeast mitotic cycle.

2. Cell cycle control by an essential bacterial two-component signal transduction protein.

3. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.

4. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae.

5. The Saccharomyces cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6.

6. The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.

7. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.

8. A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase.

9. A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

10. Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast.

1. Novel role for an HPt domain in stabilizing the phosphorylated state of a response regulator domain.

Review 2. Regulation of the transcriptional response to oxidative stress in fungi: similarities and differences.

3. Identifying cooperativity among transcription factors controlling the cell cycle in yeast.

4. Network component analysis: reconstruction of regulatory signals in biological systems.

Review 5. Fungal Skn7 stress responses and their relationship to virulence.

6. Histidine kinase two-component response regulator proteins regulate reproductive development, virulence, and stress responses of the fungal cereal pathogens Cochliobolus heterostrophus and Gibberella zeae.

7. Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus.

8. The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p.

9. cDREM: inferring dynamic combinatorial gene regulation.

10. LuxU connects quorum sensing to biofilm formation in Vibrio fischeri.