Literature DB >> 10511710

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

J R Bischoff1, G D Plowman.   

Abstract

Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis. Proper chromosome segregation and cytokinesis ensure that each daughter cell receives the full complement of genetic material. Defects in these processes can lead to aneuploidy and the propagation of genetic abnormalities. This review discusses the Aurora/Ipl1p kinases in terms of their protein structure and proposed function in mitotic cells and also the potential role of aurora2 in human cancer.

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Year:  1999        PMID： 10511710     DOI： 10.1016/s0962-8924(99)01658-x

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  103 in total

1.  The NPK1 mitogen-activated protein kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis.

Authors:  R Nishihama; M Ishikawa; S Araki; T Soyano; T Asada; Y Machida
Journal:  Genes Dev       Date:  2001-02-01       Impact factor: 11.361

2.  The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

Authors:  C M Pfleger; M W Kirschner
Journal:  Genes Dev       Date:  2000-03-15       Impact factor: 11.361

3.  Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells.

Authors:  Patrick Meraldi; Reiko Honda; Erich A Nigg
Journal:  EMBO J       Date:  2002-02-15       Impact factor: 11.598

Review 4.  Control of plant cytokinesis by an NPK1-mediated mitogen-activated protein kinase cascade.

Authors:  Takashi Soyano; Masaki Ishikawa; Ryuichi Nishihama; Satoshi Araki; Mayumi Ito; Masaki Ito; Yasunori Machida
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2002-06-29       Impact factor: 6.237

5.  Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.

Authors:  Joan Roig; Alexei Mikhailov; Christopher Belham; Joseph Avruch
Journal:  Genes Dev       Date:  2002-07-01       Impact factor: 11.361

6.  Changing roles of aurora-B kinase in two life cycle stages of Trypanosoma brucei.

Authors:  Ziyin Li; C C Wang
Journal:  Eukaryot Cell       Date:  2006-07

7.  Functional interaction of Aurora-A and PP2A during mitosis.

Authors:  Virginie Horn; Jacques Thélu; Alphonse Garcia; Corinne Albigès-Rizo; Marc R Block; Jean Viallet
Journal:  Mol Biol Cell       Date:  2007-01-17       Impact factor: 4.138

8.  A small C-terminal sequence of Aurora B is responsible for localization and function.

Authors:  Laetitia Scrittori; Dimitrios A Skoufias; Fabienne Hans; Véronique Gerson; Paolo Sassone-Corsi; Stefan Dimitrov; Robert L Margolis
Journal:  Mol Biol Cell       Date:  2004-10-27       Impact factor: 4.138

9.  NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.

Authors:  Daisuke Mori; Yoshihisa Yano; Kazuhito Toyo-oka; Noriyuki Yoshida; Masami Yamada; Masami Muramatsu; Dongwei Zhang; Hideyuki Saya; Yoko Y Toyoshima; Kazuhisa Kinoshita; Anthony Wynshaw-Boris; Shinji Hirotsune
Journal:  Mol Cell Biol       Date:  2006-10-23       Impact factor: 4.272

10.  MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.

Authors:  Kara Hoar; Arijit Chakravarty; Claudia Rabino; Deborah Wysong; Douglas Bowman; Natalie Roy; Jeffrey A Ecsedy
Journal:  Mol Cell Biol       Date:  2007-04-16       Impact factor: 4.272
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